Aging & Longevity
500 peer-reviewed studies indexed
Old Blood, Young Bones: Identification of Middle-Aged Myeloid Cells That Limit Cortical Bone Loss.
Bone marrow transplantation from 40-week-old mice into young recipients increased cortical bone mass, mediated by CD11B+CD36+ myeloid cells exhibiting enriched expression of bone anabolic cytokines including Wnt6, revealing a myeloid population present during midlife that enhances cortical bone.
Reading fluency and word segmentation agreement modulate the benefits of word boundary cues for older readers in traditional Chinese.
Benefits of word segmentation cues in traditional Chinese reading were strikingly specific, emerging only for older readers with lower vocabulary knowledge and for words with clear, unambiguous boundaries, while nonword segmentation produced robust interference across all readers and measures.
The TOT-object paradigm: towards a greater understanding of speech disfluencies during tip-of-the-tongue states in older adults.
The TOT-object paradigm demonstrates that speech disfluencies (particularly silent pauses, filled pauses, conduites d'approche, and phonological errors) index word-form retrieval difficulty rather than retrieval success, and older adults produce more disfluencies than younger adults even in no-TOT conditions, suggesting age-related differences in metacognitive monitoring.
Adipose-derived mesenchymal stem cell exosomes enhance diabetic wound healing via the amelioration of fibroblast senescence through the SMARCAL1-Drp1 signaling pathway.
ADSC-Exos promote diabetic wound healing by mitigating human dermal fibroblast senescence via suppression of SMARCAL1, which enhances Drp1 transcription and restores mitochondrial dynamics.
Evaluating the Modified Barthel Index for Policy and Practice in Reablement: Lessons From Australia's Short-Term Restorative Care Program.
The Modified Barthel Index suffers from a ceiling effect in the older Australian reablement context, limiting its ability to inform evidence-based changes to program delivery in the Short-Term Restorative Care program.
Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.
Healthy aging is accompanied by distinct profiles of gray matter microstructural alterations that negatively affect memory and speed-dependent cognition, the latter of which is more pronounced after midlife.
Low intensity vibration as a novel strategy to normalize age-related deficits in T cell proliferation, activation, and function.
Low intensity vibration (LIV) at 30 Hz, 0.7g increased T cell proliferation, activation, and anti-viral functionality in aged human cells and aged mice, representing 'a novel, non-drug therapeutic strategy for ameliorating age-related declines in immune function.'
Measuring age-related differences in phonetic gradiency with the visual analogue scale and eye tracking.
Older adults displayed more categorical (as opposed to more gradient) patterns of phonetic perception than younger adults, particularly in the VAS task, where age-related differences persisted even after controlling for hearing loss and speech-in-noise perception.
Structural Relationships of Socioeconomic Factors Influencing Diet, Lifestyle Habits, Having a Dentist, and Health Factors That Impact Healthy Life Longevity for the Elderly.
Socioeconomic factors act as confounders in the association between preferred lifestyle choices (including diet and dental care) and Healthy Life Longevity, with direct effects of lifestyle habits being minimal but indirect effects operating through mental, physical, and social health and reduced disease incidence.
Cyclosporine A ameliorates ulcerative colitis by inhibiting cellular senescence, modulating the JAK2-STAT3/NF-κB signaling pathway, and regulating the gut microbiota-metabolite axis.
Cyclosporine A ameliorates DSS-induced ulcerative colitis by inhibiting cellular senescence, suppressing the JAK2-STAT3/NF-κB signaling pathway, reducing pro-inflammatory cytokines, and modulating the gut microbiota-metabolite axis to enhance intestinal barrier function.
[Morphometric OCT parameters of the lens under accommodative stimulus. Report 1. Assessment of age-related changes].
Anterior segment OCT using the CASIA2 system demonstrated statistically significant age-related changes in lens morphometric parameters under accommodative stimulus, including negative correlations with age for radii of curvature of the anterior and posterior lens surfaces and a positive correlation with lens thickness.
Measuring economic lifespan inequality: a new indicator of poverty-free lifespan across Europe.
A new indicator, Poverty-Free Lifespan Inequality, is proposed to capture heterogeneity in the distribution of poverty-free years across the population, going beyond the average measure of Poverty-Free Life Expectancy, using Sullivan-type methods and the Gini index applied to age-specific poverty prevalence data across Europe.
Effects of Age on Resting-State Cortical Networks.
Ageing was associated with frequency-specific changes in oscillatory power (decreases in low-frequency δ, θ power and increases in high-frequency β power), increased coherence across all frequency bands, and declined frontal network occurrences, providing a comprehensive electrophysiological signature for healthy ageing.
[Association between plasma 25-hydroxyvitamin D level and depressive symptom in older adults aged 65 years and above in 18 longevity areas in China].
In older adults aged ≥65 years from 18 longevity areas in China, plasma 25(OH)D level was significantly associated with the risk for depressive symptom, showing a monotonically decreasing dose-response relationship.
Higher sleep quality predicts lower risk of depressive symptoms: A prospective analysis from the English longitudinal study of ageing.
Better self-reported sleep quality was independently associated with a lower risk of depressive symptoms in older adults, with good sleep quality associated with a 69% lower risk compared to poor sleep quality.
Development and validation of a machine learning model for frailty screening using claims data in Japan: the Longevity Improvement & Fair Evidence Study.
A machine learning model using administrative claims data achieved reasonable performance (ROC-AUC 0.780 internal, 0.728 external) for frailty screening and was associated with significantly higher mortality risk (hazard ratio ~7) in frailty-classified individuals.
Automatic pairing of real-world stimuli in younger and older adults: An event-related potential study.
Task-irrelevant, thematically unrelated visual events can become associated through temporal proximity, but violations of these associations evoke neural responses distinct from vMMN that vary across age groups, with older adults relying on later, potentially semantic-related mechanisms rather than early visual processes.
Imidacloprid exposure at population-relevant doses induces hepatic lipid dysregulation: Exploring the role of cGAS-STING pathway-mediated hepatocyte senescence.
IMI exhibits chronic hepatotoxicity at human-relevant exposure levels, inducing hepatic lipid dysregulation through cGAS-STING pathway-mediated hepatocyte senescence.
Sensorimotor Adaptation to a Nonuniform Formant Perturbation Is Preserved in Healthy Aging.
Healthy aging does not impair sensorimotor adaptation in speech, as older adults adapted to a nonuniform formant perturbation and generalized this learning to untrained vowels to the same degree as younger adults.
Vagus nerve stimulation alters task-evoked pupillary responses in older but not younger adults: A single-blind active sham-controlled crossover trial.
VNS affects LC-related physiological measures differently across age groups, with older adults showing more robust responses, possibly reflecting different baseline LC activity states.
[Results of the program to preserve cognitive skills and psycho-emotional health in Moscow Longevity Centers].
Computer cognitive training and EEG-based biofeedback training demonstrated high potential effectiveness as non-drug methods to support cognitive and psycho-emotional health in persons aged 55 and older, with statistically significant improvements observed in the vast majority of participants.
Chronological age, proton pump inhibitors in older adults, and diabetes in older adults on physicochemical characteristics of contents of the descending duodenum during fasting: An exploratory study.
The effect of chronological age, PPIs in older adults, and/or Type II diabetes in older adults on pH, buffer capacity, or bile acid concentrations in fasted duodenal contents appears to be too small to impact oral drug absorption.
Age-dependent efficiency of magnetic drug targeting in young and old patient-specific aortic models.
Vascular aging enhances magnetophoretic drug capture under realistic hemodynamic conditions, with older patients consistently exhibiting slightly higher capture efficiency than younger patients, underscoring the need for age-aware optimization in patient-specific MDT strategies.
The financial toxicity of ageing: a longitudinal analysis of the health and functional determinants of household OOP spending in rural South Africa.
The financial toxicity of ageing in rural South Africa is characterised by a 'dual burden of exclusion' whereby NCD diagnoses drive households into OOP spending while severe functional and mental decline acts as a barrier to access, effectively excluding the most vulnerable from the formal health economy.
Brain age prediction in a multiethnic Asian population: A comparison of machine learning algorithms and their application for early-stage cognitive impairment diagnosis.
An interpretable ensemble machine learning model using structural MRI provides a robust BrainAGE biomarker capable of detecting early cognitive decline in multiethnic Asian populations.
The World Health Organization ageism towards older persons scale: preliminary validation of a novel measure of ageist stereotypes, prejudices, and discrimination in four different countries.
The WHO Ageism Towards Older Persons Scale (WHO-A-TOPS) demonstrated acceptable partial scalar measurement invariance across four countries and across age groups, supporting its use as a common measure of ageist stereotypes, prejudices, and discrimination.
"There's no place like home, but…": dependent older adults' narratives on the health and well-being limits of ageing in place.
Ageing in place among dependent older adults should be understood as a conditional and relational process rather than a universal ideal, shaped by three interconnected boundaries: deteriorating health, perceived burden on family members, and loneliness.
Spontaneous HRV fluctuations are linked to functional changes in resting state brain activation in younger and older adults.
Spontaneous HRV fluctuations are linked to functional changes in resting state brain activation involving the ACC, cerebellum, brainstem, and temporal lobe, with these brain-heart communication patterns showing age invariance between younger and older adults.
Association of loneliness and perceived social exclusion with donation behavior among community-dwelling individuals aged 40 and over: longitudinal evidence from the nationally representative German Ageing Survey.
Increases in perceived social exclusion were significantly associated with lower odds of donation across all models, while the association between loneliness and donation became insignificant after accounting for lifestyle and health-related covariates.
A common signal-strength factor limits awareness and precise knowledge of multiple moving objects across the adult lifespan.
A single signal-strength parameter (d') explained both precise knowledge and awareness of multiple moving objects, and this parameter significantly declined with observers' age, while a recollection-based parameter (R) played only a small role and did not vary with age.
Placing the Dominant Foot Behind Reduces Postural Sway During Tandem Stance (Heel-to-Toe) Across Age Groups.
Center-of-pressure displacement was reduced when the dominant foot was placed at the back during tandem stance for both visual conditions and across all age groups, underscoring the importance of considering foot dominance when assessing postural control.
Temporal dynamics of blood pressure, functional status and cognitive function in adults aged 85 years and older: a dynamic time warping approach in the Leiden 85-plus study.
BP changes were associated with subsequent inverse IADL changes over time, while changes in diastolic BP preceded concordant changes in cognitive function, highlighting the importance of BP changes in old age as they might indicate later functional or cognitive decline.
[Association between physical activity and non-alcoholic fatty liver disease among adults aged 65 and above in longevity regions of China].
Physical activity level is inversely associated with the prevalence of non-alcoholic fatty liver disease among elderly adults aged 65 and above in 18 longevity regions of China.
Do age and episodic memory task performance differentially relate to tract-specific white matter microstructure? Cross-sectional and longitudinal analyses in a healthy adult sample.
Episodic memory measured by delayed free recall may have more subtle associations with white matter microstructure maintenance than it does with chronological age, with WMM predicting delayed recall performance only in the fornix above and beyond variance explained by age in cross-sectional analyses.
[Association between physical activity and sarcopenia among older adults aged 65 and above in longevity areas of China].
Increased total physical activity and active engagement in household or leisure activities are associated with a reduced risk of sarcopenia among older adults in longevity areas of China.
[Association between body composition and high-sensitivity C-reactive protein in older adults aged 65 years and above in 18 longevity areas in China].
Higher muscle mass might mitigate inflammation risk, while increased fat mass, body fat percentage, and visceral fat level might exacerbate the risk in older adults, with sex-specific differences existing in these associations.
Age-related digestive capacity decline modulates the kinetic patterns of starch and protein digestion from varied diets: An in vitro study.
Compositional variations among Mediterranean, Southern European Atlantic, Japanese, and Chinese diets regulated protein and starch digestive characteristics in adults and older adults, with the C-diet appearing particularly suitable for older adults due to its favorable peptide release.
[Epidemiological characteristics of chronic pain and influencing factors in older adults aged 65 years and above in 18 longevity areas in China].
The prevalence of chronic pain was relatively high (61.25%) in older adults aged ≥65 years in 18 longevity areas in China, with significant area, age, and gender differences, and depression, female sex, obesity, and hypertension among the key influencing factors.
Accuracy of owner-reported diagnoses for dogs enrolled in the Dog Aging Project as compared to veterinary electronic medical records.
Owner-reported dog health data showed substantial concordance with veterinary electronic medical records for many disease categories, supporting their utility as a reliable and scalable supplement or alternative to VEMRs in veterinary research and epidemiology.
Intrarenal renin-angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes.
Intrarenal renin-angiotensin system promotes tubulopathy in diabetic kidney disease through NOX4-induced mitochondrial oxidative stress and dysfunction in proximal tubules and oxidative DNA damage-induced senescence in distal tubules.
The neural substrates of enhanced response Inhibition induced by attentional capture in older adults with a higher moderate-to-vigorous physical activity: a VBM and resting-state functional connectivity study.
MVPA is positively associated with response inhibition in older adults, and the positive relationship is associated with effective attentional resource allocation for faster attentional capture, with distinct frontal subregions participating in different cognitive processes involved in response inhibition.
Age(ncy) differences: Age-related changes in the use of sense of agency cues.
Authorship ratings decreased with increasing action-effect interval in younger adults but not in older adults, indicating that temporal agency cues are used differently across different age groups.
Deep Learning-Based Estimated Pulmonary Biological Age From Chest Computed Tomography Images in Healthy Adults: Model Development and Validation Study.
This study developed and validated an estimated pulmonary biological age (ePBA) biomarker using deep learning models based on chest CT images from healthy adults, and found that the age gap (ePBA minus chronological age) was significantly associated with reduced lung function and increased all-cause mortality in patients with COPD.
Diverging trajectories of depressive symptoms after retirement: the moderating role of social engagement.
Depressive symptoms rose sharply after retirement and persisted for more than 4 years, but high informal social engagement buffered against sustained psychological decline, producing only a temporary rise, while low social engagement was associated with sustained increases that did not return to preretirement levels even after 4 years.
Experiences and social constructions of loneliness in later life: Collaborative focus group discussions in Germany.
Older adults experiencing loneliness associated with ageing in place report poor quality of social contact, negative physical and mental consequences, and fluid boundaries between emotional and social loneliness, suggesting health professionals serve as an important social interface and that mere quantification of social contacts is insufficient for evaluation or intervention design.
Family member bereavement, salivary telomere length, and all-cause mortality in older adults: Findings from the Health and Retirement Study.
Salivary telomeres did not mediate relationships between loss burden and mortality, though higher loss burden and shorter telomeres each independently predicted higher odds of mortality, with unexpected race-stratified findings showing positive associations between certain loss exposures and telomere length among Hispanic and Black participants.
Ketone Monoester Increases Skeletal Muscle Power and Energy Turnover in Older but Not Young Men Without Affecting Metabolic Economy: A Controlled, Double Blind, Cross-Over Trial.
Ketosis enhanced skeletal muscle work capacity and ATP production in older but not young adults, suggesting an age-specific effect of ketone bodies on muscle function that operates independently of changes in metabolic economy and mitochondrial function.
Impact of cognitive load on pupil dilation: A comparative study of young and older adults.
Although working memory performance was largely preserved in older adults, their attenuated pupillary responses to increasing task demands may reflect early functional alterations in the LC-NA system, suggesting pupillary reactivity as a promising non-invasive biomarker of cognitive control and age-related neural integrity.
A three-stage neurocognitive model of facial age processing: Evidence from ERP, oscillatory dynamics, and functional connectivity.
Facial age processing follows a three-stage neurocognitive model—structural encoding, prototype matching, and affective evaluation—characterized by a dynamic shift from early global coordination to later localized processing, as evidenced by stage-specific ERP effects, oscillatory dynamics, and functional connectivity patterns.
Associations of war-related exposures and early life adversity with late-life cognition.
Both war exposures and early life adversity likely impact cognitive aging in nuanced ways, with displacement associated with lower executive function, greater ELA associated with better executive function and language scores, and family endangerment associated with poorer visuospatial skills.