Forcslim (Coleus forskohlii extract) demonstrated significant anti-obesity effects including reductions in body weight, waist circumference, and improvements in lipid profile, suggesting it may serve as a safe and effective alternative to synthetic anti-obesity drugs.
Forcslim supplementation produced a significant reduction in body weight compared to placebo over 12 weeks.
Forcslim supplementation produced a significant reduction in waist circumference compared to placebo.
Triglyceride levels were significantly reduced in the Forcslim group.
HDL (high-density lipoprotein) cholesterol levels showed a significant increase in the Forcslim group.
Forcslim demonstrated a favorable safety profile with no clinically significant adverse changes observed.
This research suggests that a standardized extract of Coleus forskohlii, a plant used in traditional medicine, may help overweight people lose weight and improve their metabolic health. In a 12-week clinical trial with 60 overweight adults, those taking the Coleus forskohlii supplement (called Forcslim) lost nearly 2 kilograms more than those taking a placebo, and also reduced their waist circumference by about 1.8 centimeters more. Blood fat (triglyceride) levels dropped significantly, and 'good' cholesterol (HDL) levels rose significantly in the supplement group. Importantly, the supplement appeared to be safe based on standard medical tests. No meaningful changes were detected in markers of liver health, kidney function, muscle health, heart rate, or blood pressure, and participants did not report notable side effects. These safety results suggest that Coleus forskohlii extract was well tolerated over the 12-week period in this population. This research suggests that Coleus forskohlii extract could be a plant-based option to support weight management and cardiovascular risk factor improvement in overweight individuals. However, it is worth noting that the study used a 'quasi-randomized' design rather than fully randomized allocation, and the sample size was relatively small (60 participants), so further large-scale trials would help confirm these findings.
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Upload Your LabsChannangihalli Thimmegowda S, Hussain Mirza F, Venkataraman R, Nagarajaiah R. (2026). A 12-week, double-blind, quasi-randomized, placebo-controlled study to evaluate the efficacy and safety of Coleus forskohlii (Forcslim) on body weight loss.. Journal of the International Society of Sports Nutrition. https://doi.org/10.1080/15502783.2026.2725137