A 16-week supplementation with a polyphenol-rich supplement, Sinetrol® Xpur, aids in fat loss of overweight and obese volunteers: a randomised, double-blind, parallel trial.

Total fat percentage significantly decreased in the polyphenol-supplemented group compared to placebo after 16 weeks.

• Total fat% decreased by 1.98% (SD 3.5) in the polyphenol-supplemented group after 16 weeks compared to the placebo group.
• The study included 77 overweight and obese but otherwise healthy men and women.
• Participants received either placebo or Sinetrol® Xpur at a dose of 900 mg/day.
• Participants followed a normocaloric diet and continued their usual physical activity during the study.

Resting energy expenditure increased within the polyphenol-supplemented group over the 16-week intervention.

• The increase in resting energy expenditure within the polyphenol-supplemented group was statistically significant (p = 0.02).
• This finding was observed within the supplemented group over the 16-week period.
• The trial was a randomised, double-blind, parallel design.

There was a trend towards increased lean mass in the polyphenol-supplemented group compared to placebo.

• The trend towards an increase in lean mass compared to the placebo group did not reach statistical significance (p = 0.06).
• This finding accompanied the significant decrease in total fat percentage observed in the supplemented group.
• The study duration was 16 weeks with an additional 4-week follow-up period.

The polyphenol supplement may have helped prevent the regain of fat during the 4-week follow-up period after the intervention.

• A 4-week follow-up period was included after the 16-week supplementation period.
• The authors noted the supplement intake 'may help prevent the regain of fat during the 4-week follow-up.'
• This observation was based on body composition measurements taken at the follow-up visit.

Sinetrol® Xpur supplementation at 900 mg/day was safe and well-tolerated over 16 weeks.

• All safety parameters were within normal ranges throughout the study.
• No adverse effects were noticed during the 16-week supplementation period.
• The study population consisted of overweight and obese but otherwise healthy men and women.
• The trial was registered under NCT04149158.