A Conceptual Digital Health Framework for Longevity Optimization: Inflammation-Centered Approach Integrating Microbiome and Lifestyle Data-A Review and Proposed Platform.

Specific nutritional interventions are associated with up to 23% lower all-cause mortality in Blue Zone populations and Mediterranean diet studies.

• Evidence drawn from Blue Zone populations and Mediterranean diet studies.
• Part of the mortality association may be mediated by measurable improvements in inflammatory biomarkers.
• This represents a synthesized finding from published literature rather than a novel trial conducted by the authors.

Mediterranean dietary interventions reduce high-sensitivity C-reactive protein (hs-CRP) by 18-32% across multiple randomized controlled trials.

• Evidence synthesized from 'multiple randomized controlled trials' of Mediterranean dietary interventions.
• hs-CRP reduction range reported as 18-32%.
• Metabolic markers including HOMA-IR and TG/HDL ratios were also reported to improve.

Mediterranean dietary interventions increase microbiome diversity by 6-28% based on published randomized controlled trial evidence.

• Microbiome diversity improvement range reported as 6-28%.
• Evidence synthesized from multiple randomized controlled trials.
• Microbiome data were incorporated alongside inflammatory biomarkers in the proposed framework.

Digital health platforms demonstrate sustained engagement rates of 58-84% at 12 months, with dietary logging frequencies of 4-6 days per week.

• Sustained engagement range at 12 months: 58-84%.
• Dietary logging frequency reported as 4-6 days per week.
• These figures are drawn from published digital health platform studies cited in the review.

Cost-effectiveness analyses of dietary interventions show incremental cost-effectiveness ratios (ICERs) of USD 2100-4800 per quality-adjusted life year (QALY) gained.

• ICER range: USD 2100-4800 per QALY gained.
• These figures are derived from published cost-effectiveness analyses of dietary interventions.
• The authors cite this range as supporting the scalability of an inflammation-centered digital health framework.

The paper proposes the Longevity-Inflammation Index (L-II), a composite score combining hs-CRP, interleukin-6, tumor necrosis factor-alpha, and microbiome-derived markers.

• The L-II integrates four marker categories: hs-CRP, IL-6, TNF-alpha, and microbiome-derived markers.
• Scoring algorithms are described as derived from centenarian population studies.
• The L-II is a conceptual construct proposed in this paper and has not yet been validated in clinical trials.

The proposed digital health framework integrates quarterly inflammation and microbiome monitoring with continuous lifestyle tracking to deliver personalized longevity interventions.

• The platform leverages artificial intelligence to generate evidence-based recommendations.
• Recommendations are described as adapted from centenarian and Mediterranean dietary patterns.
• The framework synthesizes evidence from Mediterranean diet trials, centenarian microbiome studies, and digital health platforms.
• The authors note that validation studies are needed to confirm the integrated platform's efficacy and real-world implementation feasibility.

Chronic low-grade inflammation ('inflammaging') is described as a central mechanism linking dietary patterns, gut microbiome composition, and biological aging.

• The concept of 'inflammaging' frames the paper's theoretical foundation.
• The framework positions inflammatory biomarkers as measurable mediators between diet, microbiome, and aging outcomes.
• This framing is used to justify integrating inflammation monitoring as the central component of the proposed platform.