Cardiovascular

A Link Between the Triglyceride-Glucose Index and the Risk of Hypertension Among Employees in the Titanium Dioxide Industry.

TL;DR

A high TyG index increases the risk of hypertension among workers in titanium dioxide production enterprises, with the highest TyG quartile showing 11.12 times higher hypertension risk than the lowest quartile.

Key Findings

The prevalence of hypertension among titanium dioxide manufacturing workers was 17.22%.

  • Cross-sectional study of 596 employees at a titanium dioxide manufacturing enterprise in Guangxi
  • Participants underwent questionnaire surveys and health examinations
  • Hypertension prevalence of 17.22% was identified in this occupational population

Univariate analysis identified multiple factors associated with hypertension risk in TiO2 workers.

  • Age, gender, work experience, alcohol consumption, hyperglycemia, abnormal liver function, dyslipidemia, and the TyG index were all associated with hypertension (P < 0.05)
  • The TyG index was among the variables reaching statistical significance in univariate analysis

Multivariate analysis revealed that workers in the highest TyG index quartile had 11.12 times greater hypertension risk compared to those in the lowest quartile.

  • Odds ratio for Q4 vs Q1: 11.12 (95% CI: 3.52–35.16)
  • Analysis was performed using multivariate logistic regression
  • The TyG index was examined across four quartiles (Q1 through Q4)

The restricted cubic spline model revealed a nonlinear association between the TyG index and hypertension risk.

  • P for overall < 0.0001
  • P for nonlinearity < 0.0001
  • The nonlinear relationship suggests the association between TyG index and hypertension risk is not simply linear across the range of TyG values

Stratified analysis confirmed the TyG index as a major risk factor for hypertension with a positive effect across subgroups.

  • Stratified analysis showed P < 0.05 across subgroups
  • The TyG index maintained a positive association with hypertension risk in stratified analyses
  • This finding supports the consistency of the TyG-hypertension association in this occupational population

The TyG index demonstrated good predictive ability for hypertension as measured by ROC curve analysis.

  • Area under the ROC curve (AUC) was 0.775
  • An AUC of 0.775 was characterized as indicating 'good predictive ability' for hypertension
  • The TyG index was described as 'a low-cost, easily implemented early screening tool' based on these results

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Citation

Qin F, Qi G, Sooranna S, Lu J, Tian H, Lu F, et al.. (2026). A Link Between the Triglyceride-Glucose Index and the Risk of Hypertension Among Employees in the Titanium Dioxide Industry.. Vascular health and risk management. https://doi.org/10.2147/VHRM.S567638