A Pilot Randomized Controlled Trial and Multi-Omics Analysis of Electrolysed Alkaline Water: Impacts on Gut Microbiota and Metabolic Signatures in Hyperuricemia.

The EAW group exhibited a larger reduction in serum uric acid than the control group after 12 weeks of intervention.

• Study design: 12-week randomized controlled trial in 40 adults aged 18-65 years with elevated serum uric acid (SUA)
• Participants consumed either 1.5 L/day of EAW (pH 8.5-9.5) or purified water (pH 7.0)
• The reduction in serum uric acid in the EAW group was described as 'modest'
• The trial was registered under ChiCTR2500100190

EAW consumption was associated with improvements in selected physical health-related quality-of-life measures compared to the control group.

• Quality of life was assessed using the SF-36 instrument
• Improvements were observed specifically in 'selected physical health-related quality-of-life measures'
• The abstract does not specify which SF-36 subscales showed improvement
• Assessment was conducted over the 12-week intervention period

Modest differences in gut microbial composition were observed between the EAW and control groups.

• Gut microbiota was comprehensively assessed as part of a multi-omics analysis
• Differences in microbial composition were characterized as 'modest'
• Both gut microbiota and gut metabolomics were assessed to evaluate intervention efficacy and explore potential mechanisms
• The abstract does not specify which microbial taxa were differentially abundant

Metabolomic analyses identified group-level differences in metabolites enriched in pathways related to purine metabolism and other urate-associated metabolic processes.

• Gut metabolomics was used as part of the multi-omics assessment
• Metabolite differences were enriched in 'purine metabolism and other urate-associated metabolic processes'
• These metabolomic findings were described as exploratory
• The analyses were conducted alongside gut microbiota profiling to explore mechanisms of EAW action

Hyperuricemia is the second most common metabolic disease in China, with a prevalence of 24.5% in males and 3.6% in females.

• Hyperuricemia can induce multiple complications such as gout and diabetes
• Existing urate-lowering drugs have 'significant hepatorenal toxicity,' necessitating safe lifestyle interventions
• EAW as daily drinking water had shown 'preliminary effectiveness' prior to this trial but lacked randomized controlled evidence
• This trial was designed to address the gap in mechanistic studies 'at the microbiome-metabolome interface'