A Randomised Controlled Trial Comparing the Effects of Personalised Diet and Physical Activity Intervention Versus Usual Care on Cardiometabolic Risk Factors in Adults with Inactive Inflammatory Bowel Disease.

Adults with IBD in remission had a high prevalence of modifiable cardiometabolic risk factors at baseline.

• High waist circumference was present in 88% of participants
• Abnormal lipid profile was present in 56% of participants
• Participants were required to have a BMI > 25 kg/m2 and low fibre intake < 25 g/day for inclusion
• 85% of participants had faecal calprotectin < 150 µg/g, confirming disease remission

The 6-month personalised diet and physical activity intervention did not produce significant between-group differences in the primary outcome of body fat change.

• 64 participants were randomised across three hospitals in New Zealand from 2023 to 2024
• 51 participants (80%) completed the intervention
• Between-group differences were analysed using multivariable regression
• No significant differences were found in body fat (primary outcome) between the personalised intervention and usual care groups

The personalised intervention produced significant improvements in dietary intake compared to usual care.

• Fruit intake increased by 0.5 serves/day (95% CI: 0.1, 1.0)
• Dietary fibre increased by 3.1 g/1000 kcal/day (95% CI: 1.1, 5.1)
• Discretionary food and drink intake decreased by 1.7 serves/day (95% CI: -3.0, -0.3)
• Sodium intake was reduced by 911 mg/day (95% CI: -1783, -40)

No significant between-group differences were observed in secondary outcomes including disease activity, biomarkers, and quality of life.

• Secondary outcomes included disease activity, biomarkers, quality of life, and physical activity
• Dietary changes including increased fibre intake did not exacerbate IBD disease activity
• Personalised intervention was based on the New Zealand Heart Foundation heart-healthy eating guidelines paired with a self-led physical activity program
• Control group received generic healthy eating and physical activity education

The study population was predominantly female with Crohn's disease and middle-aged.

• Median age was 47 years (LQ, UQ: 37, 55)
• 59% of participants were female
• 61% had Crohn's disease
• Participants were recruited from three hospitals in New Zealand

The authors concluded that more intensive physical activity modalities may be needed to support body composition improvements in adults with IBD.

• The self-led physical activity program used in this trial was not sufficient to produce significant body composition changes
• The intervention was 6 months in duration
• Authors recommend more intensive activity modalities to support body composition improvements
• Personalised dietitian advice was considered effective for producing meaningful dietary changes