Gut Microbiome

A study on the role of Tai Chi training in improving type 2 diabetes mellitus.

TL;DR

Tai Chi training can improve blood glucose homeostasis, gut microbiota richness and diversity, intestinal mucosal barrier function, and systemic inflammatory status in T2DM patients.

Key Findings

Six months of Tai Chi training significantly reduced body composition measures in T2DM patients.

  • 36 patients with T2DM underwent 6 months of Tai Chi training
  • Significant reductions were observed in body weight, BMI, waist circumference, and body fat percentage (p < 0.05)
  • Lean body mass increased significantly (p < 0.05)
  • Body composition was measured as part of a broader assessment including biochemical indicators

Tai Chi training significantly improved glycemic control and lipid markers in T2DM patients.

  • Fasting blood glucose, glycated hemoglobin, and insulin resistance index (HOMA-IR) decreased significantly (p < 0.01)
  • Total cholesterol levels also decreased significantly (p < 0.01)
  • Measurements were taken before and after the 6-month intervention period
  • Biochemical indicators were assessed as part of the study's outcome measures

Tai Chi training significantly reduced pro-inflammatory markers and increased the anti-inflammatory factor IL-10.

  • CRP, TNF-α, IL-6, IL-1β, and IL-8 levels decreased significantly (p < 0.01)
  • The anti-inflammatory factor IL-10 increased significantly (p < 0.01)
  • Serum inflammatory factors were measured as part of the study's outcome measures
  • Changes in inflammatory markers were observed across 36 T2DM patients after 6 months

Tai Chi training significantly increased gut microbiota richness and diversity in T2DM patients.

  • The Chao1 and Shannon indices increased significantly (p < 0.05)
  • Gut microbiota was assessed using 16S rRNA sequencing
  • The abundance of beneficial bacteria increased significantly, while the abundance of harmful bacteria decreased significantly (p < 0.01)
  • Gut microbiota changes were measured in 36 T2DM patients after 6 months of training

Tai Chi training significantly improved intestinal mucosal barrier function markers in T2DM patients.

  • D-lactate and zonulin decreased significantly (p < 0.01), indicating improved intestinal barrier integrity
  • Milk fat globule-EGF factor 8 (MFG-E8) increased significantly (p < 0.01)
  • These markers of intestinal mucosal barrier function were measured before and after the 6-month intervention
  • Intestinal mucosal barrier function was assessed alongside gut microbiota and inflammatory markers in 36 T2DM patients

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Citation

Yang Q, Li L, Sun M, Luo H, Zhuang C. (2026). A study on the role of Tai Chi training in improving type 2 diabetes mellitus.. Frontiers in public health. https://doi.org/10.3389/fpubh.2026.1730335