Cardiovascular

Abdominal functional electrical stimulation and binder to reduce orthostatic hypotension in individuals with a subacute spinal cord injury.

TL;DR

No single treatment condition prevented orthostatic hypotension completely, but while AFES with abdominal binder does not eliminate OH, it shows potential to mitigate BP instability during postural transitions in acute and subacute SCI.

Key Findings

The largest drops in blood pressure still met criteria for orthostatic hypotension in all four conditions, so no treatment completely prevented OH.

  • Eleven participants with SCI (C3-T5) with at least one sign or symptom of OH completed a passive sit-up test on 4 separate days, one per condition.
  • Conditions were abdominal binder (Binder), abdominal functional electrical stimulation (AFES), AFES plus binder (AFES-Binder), and no intervention (Control).
  • The largest BP drops still resulted in OH in all conditions (p < 0.001).

The Binder condition produced the largest instantaneous change in mean arterial pressure (MAP).

  • The instantaneous MAP change in the Binder condition was -41 mmHg (95% CI, -47 to -34).
  • This was the largest of the four conditions.

The AFES-Binder condition maintained mean upright MAP relative to supine, whereas mean upright MAP decreased in all other conditions.

  • AFES-Binder: -1 mmHg (95% CI, -5 to 2), p = 0.291, i.e., no significant decrease.
  • Control: -4 mmHg (95% CI, -7 to -1), p = 0.002.
  • Binder: -7 mmHg (-10 to -4), p < 0.001.
  • AFES: -6 mmHg (95% CI, -9 to -2), p < 0.001.

Mean upright MAP was highest in the AFES-Binder condition.

  • This was reported in comparison with the Control, Binder and AFES conditions.
  • BP was measured non-invasively and continuously (systolic, diastolic, and calculated MAP) across supine without treatment (5 min), supine with treatment (5 min), upright with treatment (up to 15 min), and supine post-treatment (10 min).

The authors conclude that combining AFES with an abdominal binder does not eliminate OH but may mitigate BP instability during postural transitions in acute and subacute SCI.

  • The study was a repeated measures comparative study conducted on a spinal injury inpatient ward.
  • The sample was small (n = 11) and assessed acute effects only.

What This Means

People with a recent spinal cord injury often experience sharp drops in blood pressure when they sit or stand up, known as orthostatic hypotension. This can cause dizziness and limit rehabilitation. This study tested whether an abdominal binder, electrical stimulation of the abdominal muscles (AFES), or both together could help. Eleven inpatients with injuries between C3 and T5 were tipped from lying to sitting on four different days, each with a different condition (binder, AFES, both, or nothing), while blood pressure was continuously recorded. None of the approaches completely prevented orthostatic hypotension; all conditions still showed blood pressure drops large enough to count as OH. The binder alone had the largest sudden drop in mean arterial pressure (-41 mmHg). However, when electrical stimulation and the binder were used together, average blood pressure while upright stayed essentially the same as when lying down (-1 mmHg, not a significant change). In the other three conditions, average upright blood pressure fell by about 4 to 7 mmHg. This research suggests that combining abdominal stimulation with a binder may help steady blood pressure during position changes in early spinal cord injury, even though it does not remove the problem. The study was small and looked only at immediate effects, so larger studies would be needed to confirm the benefit and see whether it lasts.

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Citation

Prajnadewie C, Blecher L, McNaughton K, Boswell-Ruys C, Luu B, Finn H, et al.. (2026). Abdominal functional electrical stimulation and binder to reduce orthostatic hypotension in individuals with a subacute spinal cord injury.. Spinal cord series and cases. https://doi.org/10.1038/s41394-026-00757-x