Adherence to Australian diet, physical activity and alcohol guidelines is associated with lower risk of depression and anxiety: a secondary analysis of the CALM trial.
Radovic L, Orr R, et al. • International journal of food sciences and nutrition • 2026
Greater adherence to Australian diet, physical activity, and alcohol guidelines was associated with reduced risk of depression and anxiety, while ultra-processed food consumption was associated with higher risk, in adults experiencing psychological distress.
Key Findings
Results
Greater diet quality was associated with reduced risk of depression and anxiety.
Risk ratio (RR) = 0.93 for diet quality and depression/anxiety outcomes
Analysis was conducted in 182 adults experiencing psychological distress
Data were pooled from both arms of a non-inferiority trial (CALM trial) comparing lifestyle-based therapy to psychotherapy
Adherence was assessed against Australian national dietary guidelines
Results
Greater physical activity adherence was associated with substantially reduced risk of depression and anxiety.
Risk ratio (RR) = 0.51 for physical activity adherence and depression/anxiety outcomes
Physical activity adherence was assessed against Australian national physical activity guidelines
This represented the largest magnitude of association among the lifestyle factors examined
Sample included 182 adults experiencing psychological distress
Results
Limited alcohol consumption in accordance with guidelines was associated with reduced risk of depression and anxiety.
Risk ratio (RR) = 0.59 for limited alcohol consumption and depression/anxiety outcomes
Alcohol consumption was assessed against Australian national alcohol guidelines
Analysis was performed in 182 adults experiencing psychological distress
Data were drawn from a secondary analysis of the CALM trial
Results
Ultra-processed food consumption was associated with increased risk of depression and anxiety.
Risk ratio (RR) = 1.03 for ultra-processed food consumption and depression/anxiety outcomes
Ultra-processed foods were examined as a specific dietary component alongside overall diet quality
This finding indicates a positive association between ultra-processed food intake and mental health risk
Analysis was conducted in a sample of 182 adults with psychological distress
Methods
The study investigated associations between adherence to multiple Australian lifestyle guidelines and mental health outcomes in adults with psychological distress.
Sample size was 182 adults experiencing psychological distress
Study design was a secondary analysis using pooled data from both arms of the CALM non-inferiority trial
Lifestyle factors examined included diet quality, physical activity, alcohol consumption, and smoking
The CALM trial compared lifestyle-based therapy to psychotherapy
Dietary components including ultra-processed foods were also examined separately from overall diet quality
Conclusions
The authors concluded that integrating lifestyle modification into mental health prevention and treatment is important, and that prescribing dietary behaviours based on national guidelines may offer practical mental health benefits.
Findings highlight the importance of integrating lifestyle modification into mental health prevention and treatment
Prescribing dietary behaviours based on national guidelines was suggested to offer practical mental health benefits
Associations were found for diet quality, physical activity, and alcohol limitation with reduced depression and anxiety risk
Ultra-processed food consumption was identified as a dietary risk factor for worse mental health outcomes
Radovic L, Orr R, Lane M, Jacka F, Jabeen T, Young L, et al.. (2026). Adherence to Australian diet, physical activity and alcohol guidelines is associated with lower risk of depression and anxiety: a secondary analysis of the CALM trial.. International journal of food sciences and nutrition. https://doi.org/10.1080/09637486.2026.2624827