Advancing global precision in dementia research: Examining Normative Heterogeneity of Aging and Neurodegeneration in Chinese Elders (ENHANCE).

The ENHANCE project was developed to address gaps in AD/ADRD research by prioritizing Chinese-speaking communities, an underrepresented but rapidly growing population in the United States and globally.

• Chinese-speaking communities are described as 'underrepresented but rapidly growing' in the US and globally
• The project specifically targets both Cantonese and Mandarin speakers
• The project addresses gaps in Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) research

ENHANCE employs a transadaptation approach to develop cognitive assessments that reflect the language and culture of Cantonese and Mandarin speakers.

• Transadaptation is distinguished from simple translation, making tools 'more relevant and appropriate' for the target populations
• The approach is designed to improve diagnostic accuracy for Chinese American elders
• Research instruments were developed with community input and pilot testing results

ENHANCE combines participant data from multiple institutional sources including UCSF, ISMMS, and the National Alzheimer's Coordinating Center (NACC).

• Data are drawn from older Chinese American participants at University of California San Francisco (UCSF) and Icahn School of Medicine at Mount Sinai (ISMMS)
• The National Alzheimer's Coordinating Center (NACC) data are also incorporated
• The multi-site data combination is used to explore 'meaningful cross-cultural differences in AD/ADRD risk and progression'

Community input and pilot testing of research instruments guided the development of the ENHANCE project.

• The project is described as 'guided by community input and pilot testing results of research instruments'
• This community-engaged approach supports the goal of making AD/ADRD research 'more responsive to language and cultural backgrounds in the older Chinese American community'
• The approach aligns with the broader goal of 'precision medicine in diverse populations'

ENHANCE aims to support the goal of precision medicine in diverse populations by improving diagnostic accuracy and representation in AD/ADRD research for Chinese American communities.

• The stated goal is to 'improve diagnostic accuracy and representation in AD/ADRD research'
• ENHANCE is described as helping make AD/ADRD research 'more responsive to language and cultural backgrounds in the older Chinese American community'
• The project frames its contribution as 'advancing global precision in dementia research'