Cardiovascular

An Early Longitudinal Decrease in Platelet Count Is Associated With Poor Prognosis in Acute Myocardial Infarction Patients: A Multicenter Retrospective Study.

Lin T, Xu J, et al. • Clinical cardiology • 2026

PubMed 42910498 DOI 10.1002/clc.70504
TL;DR

An early longitudinal decline in platelet count was associated with a poor prognosis in patients with AMI, though the study is observational and causality cannot be inferred.

Key Findings

Results

Among 6,769 AMI patients in the eICU Collaborative Research Database, ICU 28-day all-cause mortality was 6.1% and ICU 7-day all-cause mortality was 4.6%.

  • Retrospective multicenter cohort study using data from the eICU Collaborative Research Database.
  • Total of 6,769 patients diagnosed with AMI were included.
  • Mortality was assessed at 7 and 28 days of ICU stay.
Results

During the first 5 days of ICU admission, non-survivors showed a significantly greater decline in platelet count than survivors in a generalized additive model.

  • The analysis used a Generalized Additive Model (GAM) to compare longitudinal platelet trajectories between survivors and non-survivors.
  • The comparison covered the first 5 days of ICU admission.
Results

The platelet count gap between ICU 28-day non-survivors and survivors widened by an average of 15.4 × 10^9/L per day.

  • Estimated with a Generalized Additive Mixed Model (GAMM).
  • 95% CI, 14.1 to 16.7; p < 0.001.
Results

The platelet count gap between ICU 7-day non-survivors and survivors widened by an average of 18.0 × 10^9/L per day.

  • Estimated with a Generalized Additive Mixed Model (GAMM).
  • 95% CI, 16.1 to 19.8; p < 0.001.
  • The daily widening was larger for the 7-day mortality comparison than for the 28-day comparison.
Conclusions

The authors conclude that an early longitudinal decline in platelet count is associated with poor prognosis in AMI patients, but causality cannot be inferred.

  • The study is observational and retrospective.
  • Limited prior data existed on the association between early longitudinal platelet changes and mortality.

What This Means

This study looked at records from over 6,769 heart attack patients treated in intensive care units across many US hospitals. The researchers compared how platelet counts (blood cells involved in clotting) changed over the first five days in patients who survived versus those who died. Patients who died had platelet counts that fell more over the first days in the ICU than patients who survived. The gap between the two groups grew by about 15 ×10^9/L per day for 28-day outcomes and about 18 ×10^9/L per day for 7-day outcomes. Overall, 6.1% of patients died within 28 days and 4.6% within 7 days. This research suggests that watching how platelet counts change in the first days after a heart attack could be a marker of worse outcomes. However, because this was an observational, retrospective study, it cannot show that falling platelets cause death or that acting on platelet trends would improve survival.

Have a question about this study?

Presence or severity of Hashimoto's thyroiditis does not influence basal calcitonin levels: observations from CROHT biobank.
Journal of endocrinological investigation • 2022

HT patients of all disease stages preserve Ct production as healthy individuals and there is no need for Ct measurements...
Approach to the Patient: Safety of Growth Hormone Replacement in Children and Adolescents.
The Journal of clinical endocrinology and metabolism • 2022

rhGH therapy has been used for more than 3 decades and data are largely reassuring, yet we still have much to learn abou...
Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.
Thyroid : official journal of the American Thyroid Association • 2022

PZL possesses the necessary properties to achieve a much improved T3 pharmacokinetic profile, with ~30% lower Cmax that...
Lipoprotein subtypes after testosterone therapy in transmasculine adolescents.
Journal of clinical lipidology • 2022

Testosterone appears to be a major contributor to differences in lipoprotein profiles, a surrogate for cardiovascular di...
Long-term testosterone undecanoate treatment in the elderly testosterone deficient male: An observational cohort study.
Andrology • 2022

Long-acting testosterone undecanoate treatment in elderly testosterone-deficient patients required more frequent dose ad...
Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism.
Clinical endocrinology • 2022

The Society for Endocrinology commissioned a multidisciplinary guideline to provide all care providers with a comprehens...

Citation

Lin T, Xu J, Zeng X, Liu Q, Liu M, Chen X, et al.. (2026). An Early Longitudinal Decrease in Platelet Count Is Associated With Poor Prognosis in Acute Myocardial Infarction Patients: A Multicenter Retrospective Study.. Clinical cardiology. https://doi.org/10.1002/clc.70504