An extract from whole Coffea arabica coffee cherry containing 200 mg caffeine and 15 mg polyphenols is ergogenic, improving time trial performance by 4.6%, but was not shown to enhance muscle glycogen resynthesis following post-exercise consumption of 1 g·kg bm-1 carbohydrate.
Key Findings
Results
Coffee cherry extract supplementation improved 15-minute time trial performance by 4.6% compared to placebo.
Total work performed during TT1 was 4.6% ± 1.5% greater with CB than PLA
Absolute values were 3.14 ± 0.15 vs. 3.02 ± 0.17 kJ·kg-1 for CB and PLA respectively
Effect size was moderate to large: Hedge's g = 0.8 [95% CI: 0.2, 1.4]
Statistically significant at p < 0.05
The supplement contained 200 mg caffeine and 15 mg polyphenols
Results
Perceived exertion was lower during steady-state exercise with coffee cherry extract compared to placebo.
Steady-state exercise was performed at 79 ± 1% V̇O2max for 30 minutes
Rating of perceived exertion was significantly lower in CB condition (p < 0.05)
Respiratory exchange ratio did not differ between conditions
This suggests a psychobiological rather than a substrate utilization mechanism for the ergogenic effect
Results
Plasma caffeine and chlorogenic acid concentrations were elevated in the coffee cherry extract condition throughout exercise and recovery.
Plasma caffeine and chlorogenic acid concentrations increased during exercise and subsequent recovery in CB compared to PLA (p < 0.001)
This confirmed successful absorption and bioavailability of the supplement's active components
Chlorogenic acid is the primary polyphenol measured, consistent with the coffee cherry polyphenol content
Results
Coffee cherry extract did not enhance muscle glycogen resynthesis during recovery when carbohydrate was co-ingested.
From 0 to 4 h recovery, muscle glycogen increased by 44 ± 10 mmol·kg dw-1 in CB and 64 ± 13 mmol·kg dw-1 in PLA
From 4 to 24 h recovery, muscle glycogen increased by 45 ± 10 mmol·kg dw-1 in CB and 53 ± 8 mmol·kg dw-1 in PLA
Both conditions showed significant glycogen resynthesis over time (P < 0.001), but there was no significant difference between CB and PLA
Participants consumed 1 g·kg bm-1 carbohydrate post-exercise alongside the second supplement dose
Muscle biopsies were collected at 0 h (immediately after TT1), 4 h, and 24 h to assess glycogen content
Methods
The second time trial (TT2), performed the following morning after overnight recovery, was included in the study design but performance differences are not reported in the abstract.
TT2 was performed the morning after TT1, following overnight recovery
A second supplement dose was consumed with 1 g·kg bm-1 carbohydrate after TT1
The study design was double blind, randomized, placebo-controlled, and cross-over
Mean V̇O2max was 55 ± 2 mL·kg-1·min-1, confirming trained status
Registered with clinicaltrials.gov on 10/01/2022 as NCT05404841
The supplement (CB) contained 200 mg caffeine and 15 mg polyphenols derived from whole Coffea arabica coffee cherry extract
What This Means
This research suggests that taking a supplement made from whole coffee cherry (the fruit surrounding coffee beans) before exercise can meaningfully improve cycling performance. Trained cyclists who took the supplement — which contained 200 mg of caffeine and a small amount of polyphenols (plant-based antioxidants) — performed about 4.6% better in a 15-minute maximum-effort cycling test compared to when they took a placebo. They also reported feeling like the exercise was less hard during the warm-up period before the time trial. Blood tests confirmed that both caffeine and chlorogenic acid (a polyphenol from coffee) were absorbed and circulating in the body during exercise and recovery.
However, the supplement did not appear to speed up the replenishment of glycogen — the carbohydrate fuel stored in muscles — during recovery after exercise. Both the supplement and placebo groups refueled their muscles at similar rates over the 4 hours and 24 hours following exercise, even though they consumed carbohydrates alongside the supplement. Some previous research had suggested that caffeine might help muscles store glycogen more quickly after exercise, but this study, using a relatively low dose (200 mg caffeine) combined with polyphenols from coffee cherry, did not find that benefit.
This research suggests that whole coffee cherry extract can act as an ergogenic aid — a performance enhancer — likely through caffeine's well-known effects on the brain and perception of effort, rather than by changing how the body burns fuel during exercise. The finding that glycogen resynthesis was not enhanced is practically relevant for athletes trying to recover quickly between training sessions or competitions, indicating that this particular supplement form and dose may not offer an advantage over carbohydrate alone for recovery purposes.
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Pavis G, Kingma R, Nemzer B, Abshiru N, Wall B, Stephens F. (2026). An extract from whole Coffea arabica coffee cherry improves time trial performance, but not muscle glycogen resynthesis, in trained cyclists.. Journal of the International Society of Sports Nutrition. https://doi.org/10.1080/15502783.2026.2682323