Cardiovascular

Analysis of influencing factors in patients with hypertensive intracerebral hemorrhage in the basal ganglia region treated with stereotactic surgery.

TL;DR

Age, hemorrhage location, volume of hematoma, and postoperative residual hematoma or rebleeding are independent prognostic factors for outcomes in patients with hypertensive intracerebral hemorrhage in the basal ganglia region treated with stereotactic surgery.

Key Findings

Among 116 patients with basal ganglia HICH treated with stereotactic surgery, 44.8% had favorable outcomes and 55.2% had unfavorable outcomes.

  • Study included 116 cases treated from July 2022 to December 2024, analyzed retrospectively.
  • Favorable outcome defined as mRS 0–2; unfavorable outcome defined as mRS 3–6.
  • 52 patients (44.8%) were in the favorable group; 64 patients (55.2%) were in the unfavorable group.

Older age was identified as an independent factor associated with unfavorable prognosis after stereotactic surgery for HICH.

  • Multivariate logistic regression: OR = 1.105, 95% CI: 1.049–1.164, P < 0.001.
  • Age was also significant on univariate analysis (P < 0.05).
  • Each additional year of age was associated with a roughly 10.5% increase in the odds of unfavorable outcome.

Hemorrhage location within the basal ganglia region was an independent predictor of unfavorable outcome.

  • Multivariate logistic regression: OR = 19.535, 95% CI: 1.568–243.348, P = 0.021.
  • Hemorrhage location was also significant on univariate analysis (P < 0.05).
  • The wide confidence interval suggests variability in the estimate, likely reflecting subgroup differences within the basal ganglia region.

Larger hematoma volume was independently associated with unfavorable prognosis in HICH patients treated with stereotactic surgery.

  • Multivariate logistic regression: OR = 1.095, 95% CI: 1.040–1.153, P = 0.001.
  • Volume of hematoma was also significant on univariate analysis (P < 0.05).
  • Each unit increase in hematoma volume was associated with approximately 9.5% higher odds of unfavorable outcome.

Postoperative residual hematoma or rebleeding was an independent factor associated with unfavorable outcome.

  • Multivariate logistic regression: OR = 3.606, 95% CI: 1.174–11.070, P = 0.025.
  • Patients with postoperative residual hematoma or rebleeding had approximately 3.6 times higher odds of unfavorable outcome compared to those without.
  • This factor was also significant on univariate analysis (P < 0.05).

Eight variables were significantly associated with prognosis on univariate analysis, though only four remained significant on multivariate analysis.

  • Univariate significant factors included: age, hemorrhage location, volume of hematoma, rupture into the ventricle, external ventricular drainage (EVD), preoperative Glasgow Coma Scale (GCS), postoperative residual hematoma or rebleeding, and postoperative pneumonia (all P < 0.05).
  • Rupture into the ventricle, EVD, preoperative GCS, and postoperative pneumonia did not retain independent significance in multivariate analysis.
  • Multivariate logistic regression identified four independent prognostic factors: age, hemorrhage location, hematoma volume, and postoperative residual hematoma or rebleeding.

What This Means

This research examined what factors influence recovery in patients who had a type of brain bleed called hypertensive intracerebral hemorrhage (HICH) in a deep brain region called the basal ganglia, and who were treated with a minimally invasive surgical technique called stereotactic surgery. The study looked back at records from 116 patients treated over about two and a half years. Outcomes were measured using a standard disability scale, and just under half of patients (44.8%) achieved a good recovery, while the majority (55.2%) had poor outcomes. The study found that four factors were independently linked to worse outcomes: older age, the specific location of the bleed within the basal ganglia, a larger volume of blood at the time of hemorrhage, and having leftover blood clot or re-bleeding after surgery. Several other factors — including how alert the patient was before surgery, whether blood had broken into the brain's fluid spaces, the need for an additional drainage tube, and developing pneumonia after surgery — were associated with worse outcomes in initial analyses but were not independently predictive once all factors were considered together. This research suggests that patient age and hematoma size at presentation, as well as the precise location of the bleed and surgical complications like rebleeding, are key considerations when predicting recovery for this patient population. These findings could help clinicians better identify high-risk patients and potentially guide decisions aimed at preventing post-surgical rebleeding or residual clot, which appears to be a modifiable factor influencing recovery.

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Citation

Jiang F, Yu X, Huang C, Bao Q. (2026). Analysis of influencing factors in patients with hypertensive intracerebral hemorrhage in the basal ganglia region treated with stereotactic surgery.. Neurosurgical review. https://doi.org/10.1007/s10143-026-04492-7