AngioJet rheolytic thrombectomy under superior vena cava filter protection for acute upper extremity deep vein thrombosis in patients with cancer: a single-center, retrospective analysis.
Zhai S, Yu J, et al. • Research and practice in thrombosis and haemostasis • 2026
PMT with the 8-Fr AngioJet system and SVC filter protection appears to be a safe and effective treatment option for cancer patients with acute UEDVT.
Key Findings
Results
All 19 cancer patients with acute UEDVT achieved technical success (thrombus clearance >80%) with AngioJet thrombectomy under SVC filter protection.
19 patients (10 female; mean age 60.84 ± 11.30 years) treated between January 1, 2020 and October 1, 2025 at a single center.
Technical success was defined as thrombus clearance rate >80%.
All procedures achieved technical success.
Results
No severe intraoperative adverse events and no new symptomatic pulmonary embolism occurred.
No major bleeding occurred intraoperatively.
Procedures used an 8-Fr AngioJet system (Boston Scientific) with a retrievable SVC filter in place.
Retrospective, single-center design with 19 patients.
Results
Limb swelling decreased substantially by the second postoperative day.
Mean circumference 10 cm above the elbow was 29.83 ± 2.20 cm before surgery.
It decreased to 26.98 ± 2.0 cm on postoperative day 2.
Results
All patients had secondary UEDVT with a history of malignancy, and most had a history of central venous catheterization.
All 19 patients had secondary UEDVT and a history of malignant tumors.
14 patients (73.7%) had a history of central venous catheterization.
Results
During 6-month follow-up, one patient had recurrent DVT and another had an asymptomatic mural thrombus.
One patient with advanced lung cancer developed upper limb swelling on postoperative day 136, confirmed by ultrasound as DVT recurrence.
Another patient had an asymptomatic mural thrombus found on ultrasound on postoperative day 28.
What This Means
This study looked back at 19 cancer patients who developed a recent blood clot in the veins of the arm and were treated with a catheter device (AngioJet) that mechanically removes clots. A filter was placed in the large vein near the heart (the superior vena cava) beforehand to catch any clot fragments and reduce the risk of them travelling to the lungs.
All procedures successfully cleared more than 80% of the clot. There were no serious complications such as major bleeding and no new symptomatic pulmonary embolism. Arm swelling dropped noticeably within two days. Over six months of follow-up, one patient with advanced lung cancer had clot recurrence at about day 136, and another had a small clot on the vein wall without symptoms.
This research suggests that this approach may be a safe and effective option for cancer patients with arm blood clots. However, it was a small, single-center, retrospective study with no comparison group, so larger and controlled studies would be needed to confirm these results.
Zhai S, Yu J, Sun J, Yu Y, Gao C. (2026). AngioJet rheolytic thrombectomy under superior vena cava filter protection for acute upper extremity deep vein thrombosis in patients with cancer: a single-center, retrospective analysis.. Research and practice in thrombosis and haemostasis. https://doi.org/10.1016/j.rpth.2026.107002