Application of new media-based home nursing intervention for stroke-related depression patients: a retrospective cohort study.

The intervention group showed significantly greater improvements in functional status at 6 months compared to routine care.

• Functional status was measured using the Barthel Index at baseline and 6 months post-discharge.
• The study included 107 patients with first-ever ischemic stroke assigned to either routine post-discharge care or a family-centered new-media continuous nursing intervention.
• Participation in the intervention remained independently associated with functional improvement after multivariable adjustment for baseline clinical factors.

The intervention group demonstrated larger reductions in depressive symptoms compared to the routine care group at 6 months.

• Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) at baseline and 6 months.
• The intervention group showed 'larger reductions in Patient Health Questionnaire-9 scores' relative to routine care.
• Participation in the intervention remained independently associated with psychological improvement after multivariable adjustment.

Patients in the intervention group achieved greater gains in quality of life at 6 months compared to those receiving routine care.

• Quality of life was assessed at baseline and 6 months.
• The intervention group showed 'greater gains in quality of life compared with routine care.'
• Within the intervention group, greater platform engagement was associated with larger improvements in quality of life.

Greater platform engagement within the intervention group was associated with larger improvements in depressive symptoms and quality of life.

• Platform engagement indicators were analyzed as part of the study outcomes.
• Within the intervention group, 'greater platform engagement was associated with larger improvements in depressive symptoms and quality of life.'
• This finding suggests a dose-response relationship between engagement with the new-media platform and psychological outcomes.

Rehabilitation compliance and medication adherence were higher in the intervention group than in the routine care group.

• Rehabilitation adherence and medication adherence were among the outcomes analyzed.
• The intervention group demonstrated higher rehabilitation compliance and medication adherence compared to the routine care group.
• These adherence outcomes were assessed over the 6-month follow-up period.

Patients receiving the intervention exhibited greater increases in serum brain-derived neurotrophic factor (BDNF) and endothelial progenitor cell (EPC) counts.

• Selected serum biomarkers related to neuroplasticity and inflammation were analyzed as part of the study.
• The intervention group showed 'greater increases in serum brain-derived neurotrophic factor and endothelial progenitor cell counts' compared to routine care.
• BDNF and EPC counts are biomarkers associated with neuroplasticity.

Patients receiving the intervention showed more pronounced reductions in inflammatory markers IL-6 and TNF-α compared to routine care.

• IL-6 and TNF-α are serum biomarkers related to inflammation that were analyzed in the study.
• The intervention group demonstrated 'more pronounced reductions in IL-6 and TNF-α' relative to the routine care group.
• These biological changes were observed over the 6-month follow-up period.

The study was designed as a retrospective cohort study of 107 patients with first-ever ischemic stroke receiving post-discharge care.

• The study included 107 patients with first-ever ischemic stroke.
• Patients received either routine post-discharge care or a family-centered new-media continuous nursing intervention.
• Multivariable models were used to adjust for baseline clinical factors.
• Assessments were conducted at baseline and at 6 months post-discharge.