[Application of transcatheter edge-to-edge repair in the treatment of papillary muscle rupture of mitral valve after acute myocardial infarction].

The study population consisted of 12 patients with AMI complicated by papillary muscle rupture and severe mitral regurgitation who underwent TEER.

• Mean age was 67.4 years, with 10 males and 2 females.
• 11 of 12 patients were diagnosed with ST-segment elevation myocardial infarction.
• 11 of 12 cases involved complete rupture of the posteromedial papillary muscle.
• Cardiogenic shock was present in 10 of 12 patients.
• The median Society of Thoracic Surgeons (STS) score was 51.9%, indicating extremely high surgical risk.

TEER achieved procedural success in all 12 patients, with mitral regurgitation reduced to grade ≤2+ immediately post-procedure.

• Procedural success was defined as successful grasping of the anterior and posterior mitral leaflets and reduction of mitral regurgitation to grade 2+ or less.
• 100% procedural success rate (12/12 patients).
• All patients had mitral regurgitation reduced to ≤2+ immediately after the procedure.
• No device- or procedure-related complications occurred during the perioperative period.

Eleven of 12 patients survived to hospital discharge following TEER.

• In-hospital survival rate was 91.7% (11/12 patients).
• No device- or procedure-related complications occurred during the perioperative period.
• The study was conducted at Xiamen Cardiovascular Hospital affiliated to Xiamen University from December 2021 to October 2024.

During 30-day follow-up after TEER, 2 patients died and 1 was readmitted for acute heart failure.

• Follow-up period was 30 days post-procedure.
• 2 patients died during the follow-up period.
• 1 patient was readmitted due to acute heart failure.
• At the 30-day follow-up, 9 patients maintained a mitral regurgitation grade of ≤2+.

The study was a retrospective case series examining the clinical feasibility, early efficacy, and safety of TEER in patients with AMI-complicated papillary muscle rupture.

• Retrospective analysis of 12 patients treated at a single center.
• Data collected included demographic characteristics, diagnostics and treatment processes, and in-hospital outcomes.
• Patients were followed up for 30 days post-procedure to evaluate survival status and severity of mitral regurgitation.
• The authors note findings necessitate further validation through larger-scale multicenter studies and long-term follow-up.