Bronchial asthma is an independent predictor of coronary artery disease (OR 2.02), chronic heart failure (OR 2.47), and atrial fibrillation (OR 2.49) in hypertensive patients, mandating active cardiovascular screening in this population.
The prevalence of bronchial asthma among patients in the hypertension registry was 1.1%.
The AH+BA phenotype was characterized by female predominance, older age, higher BMI, and greater prevalence of abdominal obesity compared to AH alone.
Patients with AH+BA had significantly higher rates of coronary artery disease, chronic heart failure, and atrial fibrillation compared to patients with AH alone.
After adjustment for sex and age, bronchial asthma remained an independent predictor of coronary artery disease, chronic heart failure, and atrial fibrillation in hypertensive patients.
No association was found between bronchial asthma and stroke (including transient ischemic attack) in hypertensive patients.
This research analyzed data from nearly 57,400 patients enrolled in a national hypertension (high blood pressure) registry in Russia to understand how the co-occurrence of bronchial asthma (a chronic lung disease) affects cardiovascular health. About 1.1% of hypertensive patients in the registry also had asthma. Patients with both conditions tended to be older women with higher body weight and more abdominal (belly) fat compared to hypertensive patients without asthma. They also smoked less and were less physically active. The study found that hypertensive patients with asthma had substantially higher rates of serious heart conditions: coronary artery disease (narrowed heart arteries) affected 56% of them versus 41% of those without asthma, chronic heart failure affected 69% versus 49%, and atrial fibrillation (an irregular heart rhythm) affected 10% versus 4%. Importantly, even after accounting for differences in age and sex between the groups, asthma remained an independent risk factor — roughly doubling the odds of coronary artery disease and more than doubling the odds of heart failure and atrial fibrillation. No such link was found with stroke. This research suggests that people who have both high blood pressure and asthma represent a particularly high-risk group that warrants closer cardiovascular monitoring. The findings highlight that asthma should not be viewed solely as a lung disease in this context — it appears to carry meaningful additional risk for heart complications beyond what is explained by age, sex, or other shared characteristics of the patient group.
Aksenova A, Makaryan R, Serov I, Belova O, Rachkova S, Chazova I. (2026). [Arterial hypertension and bronchial asthma: phenotype, cardiovascular complications, and independent predictors - an analysis of 57,396 patients from a hypertension registry].. Terapevticheskii arkhiv. https://doi.org/10.26442/00403660.2026.08.203727