Sleep-disordered breathing is not rare in childhood interstitial lung disease, with 77% of patients diagnosed with OSAS, and PSG alongside sleep questionnaires should be used in follow-up to improve screening and detection.
Key Findings
Results
The majority of children with interstitial lung disease were diagnosed with obstructive sleep apnea syndrome (OSAS).
77% of the 30 patients were diagnosed with OSAS
63.3% had mild OSAS and 13.3% had moderate OSAS
Study population had a mean age of 115 ± 59.3 months and 36.7% were female
This was a prospective cross-sectional single-center study
Results
REM sleep was reduced in the vast majority of children with interstitial lung disease.
REM sleep was reduced in 90% of cases
Sleep efficiency was below 85% in 20% of cases
Median AHI (Apnea-Hypopnea Index) was 1.8
All patients underwent polysomnography (PSG)
Results
Sleep questionnaires indicated impaired sleep quality and elevated SDB risk in the majority of chILD patients.
80% of patients had impaired sleep quality according to sleep questionnaires
60% showed an increased risk for sleep-disordered breathing on questionnaire screening
Both PSG parameters and sleep questionnaire scores were recorded and analyzed
Results
No significant association was found between pulmonary fibrosis and sleep-disordered breathing in children with interstitial lung disease.
Patients were compared between those with and without lung fibrosis
SDB outcomes, clinical, functional, and radiological parameters were all assessed in the comparison
The absence of an association between fibrosis and SDB was described as contrary to expectations based on adult ILD literature
Background
Adult ILD patients commonly experience poor sleep quality with abnormal sleep architecture, increased fragmentation, and sleep-disordered breathing, but the impact on children remains less studied.
childhood interstitial lung disease (chILD) is described as 'a heterogeneous group of diffuse parenchymal lung diseases'
The study was motivated by the relative lack of research on sleep in chILD compared to adult ILD
The study aimed to assess sleep quality, prevalence of SDB, and associations between SDB and clinical, functional, and radiological parameters
Conclusions
The authors recommend that polysomnography alongside sleep questionnaires should be incorporated into routine follow-up for children with interstitial lung disease.
The recommendation is based on the finding that SDB is not rare in chILD
Combined use of PSG and sleep questionnaires is advocated to 'improve screening and detection'
The study was a single-center experience with a sample of 30 patients
What This Means
This research suggests that children with interstitial lung disease (a group of serious chronic lung conditions) frequently experience sleep problems that may go undetected without proper screening. In a study of 30 children, 77% were found to have obstructive sleep apnea — a condition where breathing repeatedly stops and starts during sleep — and 90% had reduced REM (deep, restorative) sleep. Additionally, 80% of participants showed signs of poor sleep quality based on questionnaire responses.
Interestingly, the study found that the presence of lung scarring (fibrosis), which is a common complication of interstitial lung disease, was not linked to a higher likelihood of sleep-disordered breathing. This was unexpected, as it suggests that sleep problems in these children may stem from factors beyond just the structural lung damage itself.
This research suggests that sleep problems are common but potentially underrecognized in children with interstitial lung disease. The authors propose that sleep studies (polysomnography) and sleep questionnaires should be routinely included in the medical follow-up of these children, as identifying and addressing sleep-disordered breathing could be an important part of their overall care.
Oksay S, Ülgen &, Öztürk Y, Çağlar Y, Gürler E, Polat Z, et al.. (2026). Assessment of Sleep-Disordered Breathing and Sleep Quality in Childhood Interstitial Lung Disease: A Single-Center Experience.. Pediatric pulmonology. https://doi.org/10.1002/ppul.71473