Association between body roundness index and frailty in chronic obstructive pulmonary disease: A cross-sectional study of NHANES 1999 to 2018.

Higher BRI was independently associated with increased frailty risk in COPD patients, with each unit rise in BRI elevating frailty odds by 14%.

• OR: 1.14, 95% CI: 1.04-1.24 in fully adjusted models
• BRI was evaluated both as a continuous variable and in tertiles
• Adjusted weighted logistic regression models controlled for sociodemographic, lifestyle, and clinical factors
• Analysis based on cross-sectional NHANES data from 1999 to 2018

COPD patients in the highest BRI tertile had significantly increased frailty risk compared to those in the lowest BRI tertile.

• OR: 1.95, 95% CI: 1.21-3.13, P = .01
• BRI was assessed across three tertile groups
• The comparison was made between the highest and lowest tertile groups

Subgroup analyses showed a consistent positive association between BRI and frailty across examined subgroups.

• Subgroup analyses were conducted to assess consistency of the association
• The positive association between BRI and frailty was consistent across all subgroups analyzed
• No specific subgroup significantly modified the association based on the abstract

Frailty was defined using a frailty index threshold of ≥0.21 in a sample of 1151 adults with COPD aged 20 years or older.

• Sample size: 1151 adults with COPD
• Age criterion: ≥20 years
• Frailty index threshold: ≥0.21
• Data source: NHANES 1999–2018 cross-sectional surveys
• BRI was calculated from waist circumference and height

Restricted cubic spline models were used to assess the dose-response relationship between BRI and frailty in COPD patients.

• Restricted cubic spline analysis was applied alongside adjusted weighted logistic regression
• Models controlled for sociodemographic, lifestyle, and clinical factors
• The approach allowed evaluation of potential nonlinear associations between BRI and frailty