Association between cardiovascular disease and non-melanoma skin cancer: The mediation effect of obesity and inflammation.

CVD was identified as a significant risk factor for non-melanoma skin cancer (NMSC).

• Logistic regression analysis found OR: 1.83 (95% CI: 1.01–3.34, p = 0.048) for CVD as a risk factor for NMSC.
• The study included 7,424 participants from NHANES 2015–2018.
• Diagnosis of CVD and NMSC was determined by questionnaire combined with self-reported data.
• Despite the overall association, no statistically significant association was found between CVD subgroups and NMSC.

SIRI (systemic inflammation response index), BMI, and WWI (weight-adjusted waist index) partially mediated the association between CVD and NMSC.

• SIRI, BMI, and WWI each showed statistically significant partial mediation (p < .001).
• Bootstrap testing confirmed the stability of the mediation analysis results.
• SII (systemic immune-inflammation index) did not significantly alter the CVD–NMSC relationship (p > 0.05).
• Inflammatory markers and obesity indices assessed were SIRI, SII, BMI, and WWI.

SII did not mediate the association between CVD and NMSC.

• The p-value for SII as a mediator was greater than 0.05, indicating no statistically significant mediation effect.
• This contrasts with SIRI, which did show a significant partial mediation effect (p < .001).
• Both SIRI and SII are inflammatory markers, suggesting differential roles of specific inflammatory pathways in the CVD–NMSC relationship.

Logistic regression and Pearson correlation analyses were used to investigate relationships between CVD, NMSC, inflammatory markers, and obesity indices in a NHANES-based cross-sectional study.

• Data were drawn from the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2018.
• The analytic sample comprised 7,424 participants.
• Key variables included CVD status, NMSC status, and four mediator candidates: SIRI, SII, BMI, and WWI.
• Mediation analysis stability was confirmed using Bootstrap testing.