Cardiovascular

Association Between Diet Quality and 20-Year Heart Failure Incidence: Findings from the ATTICA Cohort Study (2002-2022).

TL;DR

Better diet quality, particularly greater consumption of health-promoting foods, was independently associated with lower 20-year HF incidence in a Mediterranean population.

Key Findings

HF incidence varied significantly across diet quality categories, with the lowest quality diet associated with the highest incidence.

  • HF incidence was 20.7% among participants with low diet quality, 5.1% among those with intermediate diet quality, and 6.6% among those with high diet quality (p < 0.001).
  • Among 2159 participants with available HF status at 20-year follow-up, 241 (11.2%) developed HF.
  • The ATTICA cohort enrolled 3042 adults free of cardiovascular disease at baseline (2001-2002), with follow-up conducted in 2022.

Better overall diet quality was associated with lower odds of incident heart failure over 20 years in fully adjusted analysis.

  • OR per 1-point increment in GDQS: 0.97 (95% CI, 0.94–0.99) in the fully adjusted model (n = 1973).
  • Models were sequentially adjusted for age, sex, body mass index, education, physical activity, smoking burden, hypertension, diabetes, and hypercholesterolemia.
  • Diet quality was assessed using the Global Diet Quality Score (GDQS), derived from a validated food-frequency questionnaire.

Greater consumption of healthy food components was independently and inversely associated with heart failure incidence.

  • OR for the healthy-food component of the GDQS: 0.96 (95% CI, 0.93–0.98) per 1-point increment in the fully adjusted model.
  • This association was independent of established cardiovascular risk factors including hypertension, diabetes, and hypercholesterolemia.
  • The GDQS captures the relative contributions of both healthy and unhealthy food groups.

The unhealthy-food component of diet quality was not independently associated with heart failure incidence.

  • OR for the unhealthy-food component of the GDQS: 1.04 (95% CI, 0.96–1.13), which was not statistically significant.
  • This finding suggests that the protective association of overall diet quality with HF may be primarily driven by health-promoting foods rather than reduction of unhealthy foods.
  • The fully adjusted analysis included n = 1973 participants.

The study population was a community-based Mediterranean cohort free of cardiovascular disease at baseline.

  • The ATTICA cohort included 3042 adults enrolled in 2001–2002.
  • HF status at 20-year follow-up (2022) was available for 2159 participants.
  • The study population was from a Mediterranean region, which may influence generalizability given the dietary patterns of this population.

What This Means

This research suggests that eating a higher quality diet is associated with a substantially lower risk of developing heart failure over a 20-year period. Using data from over 2,000 Greek adults followed from 2002 to 2022, researchers found that people with the lowest diet quality had a heart failure rate of nearly 21%, compared to just 5–7% in those with intermediate or high diet quality. Even after accounting for many other risk factors like age, obesity, smoking, high blood pressure, and diabetes, people who scored higher on a diet quality measure were less likely to develop heart failure. Importantly, the benefit appeared to come specifically from eating more health-promoting foods — such as fruits, vegetables, legumes, and whole grains — rather than simply from avoiding unhealthy foods. The unhealthy food component of the diet score was not independently linked to heart failure risk on its own. This distinction matters because it suggests that actively adding nutritious foods to the diet may be more impactful than just cutting out junk food. This research matters because heart failure is a serious and increasingly common condition, and diet is something people can potentially change. The findings add to a body of evidence suggesting that long-term dietary habits play an important role in heart health, and that focusing on increasing consumption of nutrient-rich, whole foods may be particularly beneficial. The study was conducted in a Mediterranean population, so results may be most applicable to similar dietary contexts, but the general principle of diet quality mattering for heart failure risk has broader relevance.

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Citation

Chrysohoou C, Iliakis P, Daha I, Leontsinis I, Mavromoustakou K, Damigou E, et al.. (2026). Association Between Diet Quality and 20-Year Heart Failure Incidence: Findings from the ATTICA Cohort Study (2002-2022).. Nutrients. https://doi.org/10.3390/nu18193278