Cardiovascular

[Association between fine particulate matter exposure and all-cause and cardiovascular mortality in urban and rural elderly population in Beijing].

TL;DR

PM2.5 exposure increases the risks for all-cause mortality and CVD mortality in the elderly population in urban and rural areas in Beijing; regular physical activity might partially offset these effects, but the protective effect is limited under extremely high pollution levels.

Key Findings

Study participants in Beijing were exposed to annual average PM2.5 levels far above the national limit.

  • The average annual PM2.5 concentration in the participants' living area was 79.80 μg/m³ from 2010 to 2014.
  • This is much higher than the national grade II limit of 35 μg/m³.
  • The analysis included 3,472 participants from the Beijing Elderly Comprehensive Health Cohort Study with complete baseline data.
  • Exposure was matched from remote sensing grid data and grouped by tertiles.

Higher PM2.5 exposure was associated with higher all-cause mortality in elderly Beijing residents.

  • Each 1 μg/m³ increase in PM2.5 was associated with a 5.3% increase in all-cause mortality risk (HR=1.053, 95%CI: 1.026-1.080).
  • Estimates came from multivariate Cox proportional hazards models adjusted for confounders.
  • Restricted cubic splines, subgroup analyses and sensitivity analyses were used to check robustness.

Higher PM2.5 exposure was associated with higher cardiovascular disease (CVD) mortality.

  • Each 1 μg/m³ increase in PM2.5 was associated with a 4.6% increase in CVD mortality risk (HR=1.046, 95%CI: 1.001-1.100).
  • The lower confidence limit is close to 1, indicating a borderline-significant association.
  • Adjusted multivariate Cox models were used.

Outdoor physical activity significantly modified the association between PM2.5 and all-cause mortality.

  • The subgroup analysis showed a significant interaction between outdoor physical activity level and PM2.5 concentration on all-cause mortality (P=0.022).
  • Among participants without outdoor physical activity, each 1 μg/m³ increase in PM2.5 was associated with an 8.7% increase in all-cause mortality risk (HR=1.087, 95%CI: 1.042-1.134).
  • Among participants with outdoor physical activity, the risk increased by 2.6% per 1 μg/m³ (HR=1.026, 95%CI: 1.001-1.062).

Among participants who did outdoor physical activity, those in the highest PM2.5 tertile still had substantially higher all-cause and CVD mortality than the reference group.

  • The highest PM2.5 tertile (T3) had a 52.3% increased all-cause mortality risk (HR=1.523, 95%CI: 1.171-1.979).
  • The T3 group had a 79.1% increased CVD mortality risk (HR=1.791, 95%CI: 1.004-3.192).
  • This indicates that the protective effect of physical activity is limited at extremely high pollution levels.

The authors conclude that regular physical activity may partially offset PM2.5 harm and recommend indoor activity on high-PM2.5 days.

  • The conclusion states that regular physical activity might partially offset the adverse health effects of PM2.5 exposure.
  • The protective effect is limited under extremely high pollution levels.
  • The authors suggest that elderly people maintain regular physical activity but exercise indoors on days when PM2.5 concentrations are high.

What This Means

This study followed 3,472 older adults living in urban and rural parts of Beijing to see whether breathing polluted air was linked to dying earlier. Between 2010 and 2014, the average yearly PM2.5 level (tiny airborne particles) where participants lived was about 80 μg/m³, more than twice China's national limit of 35 μg/m³. Higher exposure was linked to a higher chance of death from any cause and from cardiovascular disease. Each 1 μg/m³ increase in PM2.5 was associated with about a 5.3% higher risk of death from any cause and a 4.6% higher risk of cardiovascular death. The study also looked at whether being active outdoors changed this picture. Among people who did not exercise outdoors, each 1 μg/m³ increase in PM2.5 was linked to an 8.7% higher risk of death from any cause. Among those who did, the increase was 2.6%. This suggests that regular physical activity may partly offset the harm from air pollution. However, among active people living in the most polluted tertile, the risks of death were still substantially higher (52% higher for all-cause death and 79% higher for cardiovascular death) than in the reference group, so the benefit seems limited when pollution is very high. This research suggests that cleaner air matters for the health and survival of older adults, and that staying active may help but cannot fully cancel out heavy pollution. The authors propose that older people keep up regular physical activity but consider exercising indoors when outdoor PM2.5 is high. As an observational study, it shows associations rather than proving cause and effect.

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Citation

Wan Y, Du S, Chen S, Shi Y, Nie X, Wang W, et al.. (2026). [Association between fine particulate matter exposure and all-cause and cardiovascular mortality in urban and rural elderly population in Beijing].. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. https://doi.org/10.3760/cma.j.cn112338-20251204-00870