[Association between physical activity and non-alcoholic fatty liver disease among adults aged 65 and above in longevity regions of China].

The prevalence of NAFLD among elderly adults aged 65 and above in 18 longevity regions of China was approximately 29.5%.

• 963 out of 3,283 participants were identified as having NAFLD (approximately 29.5%); the Chinese abstract reports 966 (29.4%)
• NAFLD was defined based on the Fatty Liver Index (FLI) and daily alcohol intake
• The study population had a mean age of (85.57±10.77) years
• The median (Q1, Q3) PASE score was 68.60 (25.00, 111.80)

Each one interquartile range (IQR) increase in total PASE score was associated with a 20% reduction in the risk of NAFLD.

• OR=0.80, 95% CI: 0.69–0.91 after adjusting for relevant confounders
• Analysis was conducted using multivariable logistic regression models
• This association was found in the total physical activity score (PASE)
• The result was statistically significant

No statistically significant associations were observed between NAFLD risk and engaging in household activities only or leisure activities only.

• Physical activity types analyzed separately included leisure activities and household activities
• Neither household-only nor leisure-only activity showed a significant association with NAFLD in multivariable logistic regression
• Only the combined total PASE score showed a significant inverse association with NAFLD risk

The restricted cubic splines (RCS) model indicated a linear negative association between physical activity levels and NAFLD risk.

• Poverall <0.001, indicating a statistically significant overall association
• Pnon-linear=0.295, indicating no significant non-linear component and supporting a linear dose-response relationship
• The RCS model was used to analyze the exposure-response relationship between physical activity and NAFLD

The study population consisted of 3,283 elderly adults from a 2021 cross-sectional survey of the Healthy Ageing and Biomarkers Cohort Study (HABCS) across 18 longevity regions in China.

• All participants were aged 65 and above with a mean age of (85.57±10.77) years
• Physical activity was assessed using the Physical Activity Scale for the Elderly (PASE)
• Demographic characteristics, lifestyle factors, and chronic disease history were collected through questionnaires and physical examinations
• The survey was conducted in 2021 as a cross-sectional study