Associations of chronic obstructive pulmonary disease with sarcopenia and related factors: Nutritional status, body composition, antioxidant capacity, and inflammatory profile.

COPD patients had a greater risk of developing sarcopenia compared with non-COPD patients.

• A total of 112 participants were included: COPD (n = 51) and non-COPD (n = 61).
• Thirty-seven percent of COPD patients suffered from sarcopenia.
• COPD patients had lower levels of muscle function compared to non-COPD patients (P < 0.05).
• The study used a case-control design to compare sarcopenia risk between groups.

COPD patients had lower nutritional status compared with non-COPD patients.

• Nutritional status was assessed using the Mini Nutritional Assessment (MNA) and Nutritional Risk Index (NRI).
• Differences in nutritional status between COPD and non-COPD patients were statistically significant (P < 0.05).
• COPD patients were identified as being at risk for malnutrition.

Most participants had low coenzyme Q10 status regardless of COPD diagnosis.

• The threshold for low coenzyme Q10 status was defined as less than 0.5 μM.
• There was no significant difference in antioxidant capacity between COPD and non-COPD groups.
• Antioxidant capacity measures included coenzyme Q10, antioxidant enzyme activity, and total antioxidant capacity.

COPD patients had significantly different adipomyokine levels compared with non-COPD patients.

• COPD patients had greater levels of adiponectin compared to non-COPD patients (P < 0.05).
• COPD patients had lower levels of leptin compared to non-COPD patients (P < 0.05).
• Adipomyokines measured included adiponectin, leptin, and irisin.

Nutritional status was significantly associated with muscle function, antioxidant capacity, inflammatory status, adipomyokine levels, and the risk of developing COPD and sarcopenia.

• Both MNA and NRI measures of nutritional status showed significant associations (P < 0.05).
• Nutritional status was inversely associated with the risk of developing sarcopenia.
• Inflammatory markers measured included high-sensitivity C-reactive protein and interleukin-6.
• Nutritional status was found to affect antioxidant and anti-inflammatory status.