Cardiovascular

Associations of Mediterranean Diet Adherence with Cardiometabolic Outcomes, Psychological Symptoms, and Health-Related Quality of Life Among Adults Attending Primary Care Centres in Navarra, Spain: A Cross-Sectional Study.

TL;DR

Higher Mediterranean diet adherence was associated with lower blood pressure, lower fasting blood glucose, fewer anxiety symptoms, and better self-perceived health among adults attending primary care centres in Navarra, Spain, though cross-sectional findings do not establish temporality or causality.

Key Findings

Each one-point increase in the MEDAS-14 score was associated with lower systolic blood pressure.

  • β = -1.056 mmHg per one-point MEDAS-14 increase
  • 95% CI: -1.774 to -0.338
  • p = 0.004
  • Association remained statistically significant after false-discovery-rate correction
  • Exploratory interaction analyses showed evidence of interaction by sex for diastolic blood pressure after FDR correction

Each one-point increase in the MEDAS-14 score was associated with lower diastolic blood pressure.

  • β = -0.838 mmHg per one-point MEDAS-14 increase
  • 95% CI: -1.261 to -0.415
  • p < 0.001
  • Association remained statistically significant after false-discovery-rate correction
  • The overall pattern was generally consistent across sensitivity analyses

Each one-point increase in the MEDAS-14 score was associated with lower fasting blood glucose.

  • β = -0.745 mg/dL per one-point MEDAS-14 increase
  • 95% CI: -1.365 to -0.125
  • p = 0.019
  • Association remained statistically significant after false-discovery-rate correction
  • Study included 495 adults attending primary care centres in Navarra, Spain

Each one-point increase in the MEDAS-14 score was associated with fewer anxiety symptoms as measured by the Goldberg anxiety score.

  • β = -0.249 per one-point MEDAS-14 increase
  • 95% CI: -0.368 to -0.130
  • p < 0.001
  • Association remained statistically significant after false-discovery-rate correction
  • No adjusted association with Goldberg depression score was observed

Each one-point increase in the MEDAS-14 score was associated with higher EQ VAS scores, indicating better self-perceived health-related quality of life.

  • β = 1.224 per one-point MEDAS-14 increase
  • 95% CI: 0.570 to 1.878
  • p < 0.001
  • Association remained statistically significant after false-discovery-rate correction
  • Exploratory interaction analyses showed evidence of interaction by sex for EQ VAS after FDR correction

BMI was inversely associated with MEDAS-14 score in the principal linear model.

  • β = -0.299 kg/m² per one-point MEDAS-14 increase
  • 95% CI: -0.521 to -0.077
  • p = 0.009
  • Association remained statistically significant after false-discovery-rate correction
  • BMI showed evidence of non-linearity and should be interpreted cautiously

The association between MEDAS-14 score and waist circumference was not statistically significant in the adjusted model.

  • β = -0.475 cm per one-point MEDAS-14 increase
  • 95% CI: -1.046 to 0.095
  • p = 0.102
  • Waist circumference showed evidence of non-linearity
  • Total cholesterol also showed evidence of non-linearity

No adjusted association between Mediterranean diet adherence and Goldberg depression score was observed.

  • Multivariable linear regression models adjusted for age, sex, educational attainment, physical activity, and BMI when appropriate
  • Mediterranean diet adherence was assessed using the validated 14-item Mediterranean Diet Adherence Screener (MEDAS-14)
  • Study was cross-sectional, conducted among 495 adults attending primary care centres in Navarra, Spain
  • Sensitivity analyses, assessment of non-linearity, FDR correction across nine principal outcomes, and interaction-by-sex analyses were performed

Associations for BMI, waist circumference, and total cholesterol showed evidence of non-linearity.

  • Non-linearity assessment was performed as part of the analytical approach
  • These associations should be interpreted cautiously according to the authors
  • The overall pattern of associations with blood pressure, fasting blood glucose, anxiety, and EQ VAS was generally consistent across sensitivity analyses
  • The study lacked adjustment for relevant clinical diagnoses and medication use, which is noted as a limitation

What This Means

This research suggests that eating a Mediterranean-style diet — rich in vegetables, fruits, whole grains, olive oil, fish, and legumes — is linked to several health benefits in adults who visit primary care clinics in Spain. The study followed nearly 500 adults and found that those who more closely followed the Mediterranean diet tended to have lower blood pressure, lower blood sugar levels, less anxiety, and reported feeling healthier overall. These associations held up even after accounting for factors like age, sex, education level, and physical activity. Importantly, the study also found that Mediterranean diet adherence was associated with lower body weight (BMI), though the relationship between diet and BMI, waist size, and cholesterol appeared to be more complex and non-linear, meaning the benefit did not simply increase in a straight line as diet quality improved. Interestingly, while the diet was linked to lower anxiety symptoms, no similar link was found for depression. The researchers also noted that the associations with blood pressure and quality of life appeared to differ somewhat between men and women. Because this was a cross-sectional study — meaning it looked at one snapshot in time rather than following people over years — it cannot prove that the Mediterranean diet caused these health benefits. People who eat healthier may also differ in other ways that affect their health. The study also did not account for participants' medical diagnoses or medications, which could influence results. The authors call for future long-term studies to confirm whether adopting a Mediterranean diet leads to these improvements over time.

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Citation

Sulaiman Rojas J, Abell&#xe1;n Alem&#xe1;n J, Alonso Salinas G, Golac Rabanal M, Marco Detchart C, Arrechea Irigoyen I, et al.. (2026). Associations of Mediterranean Diet Adherence with Cardiometabolic Outcomes, Psychological Symptoms, and Health-Related Quality of Life Among Adults Attending Primary Care Centres in Navarra, Spain: A Cross-Sectional Study.. Nutrients. https://doi.org/10.3390/nu18193156