Associations of total physical activity with all-cause and cardiovascular disease mortality in Chinese adults: a prospective study.

Higher total physical activity was associated with significantly lower all-cause mortality in Chinese adults.

• Among 22,680 registered individuals, 1,596 adults died in total during a median follow-up of 8.2 years.
• Compared to individuals in the lowest quartile of total physical activity, those in the highest quartile had HR of 0.82 (95% CI: 0.71-0.94) for all-cause mortality.
• Restricted cubic splines revealed a nonlinear association between total physical activity and all-cause mortality.
• The cohort had a mean age of 52.7 ± 14.8 years and was 55.9% female.

Higher total physical activity was associated with significantly lower cardiovascular disease mortality.

• 630 adults died from CVD during the median follow-up of 8.2 years.
• Compared to the lowest quartile, those in the highest quartile of total physical activity had HR of 0.77 (95% CI: 0.61-0.98) for CVD mortality.
• The association was assessed using multivariable Cox proportional hazards regression models.

Higher total physical activity was associated with substantially lower ischemic stroke mortality.

• Compared to the lowest quartile, those in the highest quartile of total physical activity had HR of 0.49 (95% CI: 0.28-0.86) for ischemic stroke mortality.
• This represented a 51% reduction in ischemic stroke mortality risk for the highest versus lowest physical activity quartile.
• The analysis was conducted using multivariable Cox proportional hazards regression models.

The protective association of physical activity with mortality was significant in women, never-smokers, and never-drinkers, but not in men, smokers, or drinkers.

• Subgroup analysis showed HR of 0.87 (95% CI: 0.77-0.98) for women.
• HR for never-smokers was 0.88 (95% CI: 0.80-0.97).
• HR for never-drinkers was 0.87 (95% CI: 0.80-0.95).
• The association was not statistically significant in men, smokers, or drinkers.

The study used a prospective cohort design linking surveillance data with mortality registries in Jiangsu Province, China.

• Baseline data were collected from the Chronic Disease and Risk Factor Surveillance 2010-2015 in Jiangsu Province, with 24,288 Chinese adults initially enrolled.
• Mortality data were obtained by combining the Jiangsu Province Cause of Death Registry with active follow-up in 2021.
• After matching the two databases, 22,680 registered individuals were included in the final analysis.
• Median follow-up was 8.2 years.