Dietary Supplements

Atopic Dermatitis and Probiotic Use in Children Aged 1-4 Years: Findings from a Nationwide Survey in Serbia.

TL;DR

In a nationwide Serbian survey of 1153 children aged 1-4 years, parent-reported atopic dermatitis (23.6%) was independently associated with cesarean delivery, post-term birth, and probiotic use in the previous 12 months, though the cross-sectional design means these associations should not be read as causal.

Key Findings

Parent-reported atopic dermatitis was present in 23.6% of children aged 1-4 years in Serbia.

  • Nationwide cross-sectional online survey of parents of 1153 children aged 1-4 years.
  • AD status was parent-reported rather than clinically verified.

Cesarean delivery was independently associated with higher odds of parent-reported AD.

  • Multivariable logistic regression: aOR = 1.562; 95% CI: 1.179-2.069.
  • Adjusted for demographic, perinatal, feeding, and probiotic-related characteristics.

Post-term birth was independently associated with higher odds of parent-reported AD.

  • aOR = 1.862; 95% CI: 1.139-3.044.
  • The wide confidence interval indicates less precise estimation than for cesarean delivery.

Probiotic use during the previous 12 months was independently associated with higher odds of parent-reported AD.

  • aOR = 1.645; 95% CI: 1.214-2.231.
  • The authors caution that, because of the cross-sectional design, this should not be interpreted as evidence of a causal relationship between probiotic use and AD.

Previous probiotic use was highly prevalent among children with AD, but only a minority used probiotics for skin-related purposes.

  • Only 35.8% of children with AD were reported to use probiotics for skin-related purposes.
  • Patterns of use were analyzed among children with AD.

Parents of children with AD had slightly more favorable attitudes toward probiotics, mainly regarding their potential role in preventing AD.

  • Attitudes were measured with a three-item Likert-scale instrument.
  • The difference between parents of children with and without AD was described as slight.

The authors conclude that evidence-based parental information and guidance from healthcare professionals on probiotic use in pediatric AD are important.

  • The findings reflect a complex relationship between early-life factors, probiotic use, and AD.

What This Means

This study surveyed parents of 1153 children aged 1-4 years across Serbia about eczema (atopic dermatitis), early-life factors, and probiotic use. About 1 in 4 children (23.6%) had parent-reported eczema. Children born by cesarean section or born post-term, and those who had taken probiotics in the past year, were more likely to have eczema reported. The link with probiotics does not mean probiotics cause eczema. Because the survey captured a single point in time, it is possible that parents of children who already had eczema were more likely to give probiotics in hopes of helping. Eczema was also reported by parents, not confirmed by a doctor. Among children with eczema, probiotic use was common, but only about a third received them specifically for skin problems. Parents of children with eczema were slightly more positive about probiotics, mostly regarding preventing eczema. This research suggests that parents may be using probiotics in ways not clearly tied to skin health, and that clear, evidence-based guidance from healthcare professionals could help families make informed decisions.

Check Your Own Numbers

Upload your bloodwork. We'll cross-reference your results against this study and 4,700 others.

Upload Your Labs

Have a question about this study?

Citation

Đanić M, Marković N, Ostojić T, Stanimirov B, Milanović B, Vukmirović S, et al.. (2026). Atopic Dermatitis and Probiotic Use in Children Aged 1-4 Years: Findings from a Nationwide Survey in Serbia.. Medical sciences (Basel, Switzerland). https://doi.org/10.3390/medsci14060647