Cardiovascular

Cardiometabolic index is associated with hypertension among US older adults: An analysis of NHANES 2011-2018.

TL;DR

CMI exhibited a positive correlation with hypertension among older adults, indicating that CMI is expected to become a simple and cost-effective biomarker.

Key Findings

Participants with the highest CMI had a statistically significant 86% increased risk of hypertension prevalence compared with participants with the lowest CMI.

  • Odds ratio = 1.86; 95% confidence interval = 1.43-2.44, P < .0001 in a fully adjusted model
  • Multivariate logistic regression analysis was used to assess this association
  • The study included 3067 adults aged 60 years and older from NHANES 2011-2018

Smoothing curve fitting demonstrated a positive correlation between CMI and hypertension among older adults.

  • Smooth curve fitting was employed alongside multivariate logistic regression to investigate the association
  • The positive correlation was observed in the fully adjusted model
  • The analysis was conducted in a population of US older adults aged 60 years and older

Subgroup analyses revealed no significant interactions between CMI and specific subgroups.

  • P > .05 for all interactions across subgroups
  • Subgroup analyses and interaction tests were used to assess the stability of the association across different populations
  • The absence of significant interactions indicates the association between CMI and hypertension was consistent across different population subgroups

The study population consisted of 3067 older adults drawn from the National Health and Nutrition Examination Survey 2011-2018.

  • Participants were aged 60 years and older
  • Data spanned four NHANES survey cycles from 2011 to 2018
  • CMI was assessed as the primary exposure variable, with hypertension as the outcome

The cardiometabolic index (CMI) is described as an innovative metabolic indicator previously used for screening diabetes mellitus, stroke, and renal dysfunction.

  • CMI had not previously been investigated in relation to hypertension among older adults prior to this study
  • The authors propose CMI as a simple and cost-effective biomarker for hypertension screening
  • Hypertension is identified as the leading cause of mortality and disability-adjusted life years worldwide

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Citation

Zhou C, Wang Z, Jiang Y, Han D, Guo Y, Ren M. (2026). Cardiometabolic index is associated with hypertension among US older adults: An analysis of NHANES 2011-2018.. Medicine. https://doi.org/10.1097/MD.0000000000048188