Case Report: Lifestyle changes and probiotic supplementation for improving longstanding type 2 diabetes in a male undergoing testosterone replacement therapy.

Hemoglobin A1c decreased from 7.2% to 5.9% over 3 months without antidiabetic pharmacotherapy.

• Patient had suboptimal glycemic control with no current antidiabetic therapy at baseline.
• HbA1c reduction of 1.3 percentage points was achieved at the 3-month assessment.
• Intervention included lifestyle changes, a targeted 5-strain probiotic, and other supplements.
• Patient was a 52-year-old Caucasian male with diagnosed type 2 diabetes mellitus.

The patient demonstrated improvement in newly documented mixed hyperlipidemia at 3 months.

• Mixed hyperlipidemia was newly documented at or around the time of initial evaluation.
• Improvement was observed at the 3-month follow-up alongside glycemic improvements.
• The intervention included lifestyle changes, probiotic supplementation, and other supplements.

Testosterone levels normalized with replacement therapy by 6 months.

• The patient initially sought treatment for age-related testosterone decline.
• Testosterone replacement therapy (TRT) was initiated as part of the overall treatment plan.
• Normalization of testosterone levels was confirmed at the 6-month assessment.

The patient achieved favorable body composition changes at 6 months, including a 13.2-lb decrease in fat mass and a 5.1-lb increase in skeletal muscle mass.

• Fat mass decreased by 13.2 lbs over the 6-month period.
• Body fat percentage was reduced by 6.1%.
• Skeletal muscle mass increased by 5.1 lbs.
• These changes occurred alongside modest overall weight reduction.
• Interventions included testosterone replacement therapy, lifestyle modifications, and targeted supplementation.

The case demonstrates the feasibility of combining lifestyle interventions with targeted supplementation in a patient with metabolic syndrome who preferred non-pharmacological management strategies.

• The patient had a past medical history of both hypertension and type 2 diabetes mellitus.
• The patient qualified for testosterone replacement therapy and agreed to address metabolic dysfunction through enhanced lifestyle interventions.
• A 5-strain probiotic was included as part of the targeted supplementation regimen.
• The patient's preference for non-pharmacological management was a key factor in the treatment approach.