Mental Health

Centering transgender and gender nonconforming people of color in the study of minority stress, transition-related factors, and mental health.

TL;DR

Intersectional distal stressors were both directly and indirectly (through proximal stressors) related to anxiety and depression in TGNC people of color, and were indirectly related to reduced gender congruence through internalized proximal stressors, highlighting the importance of culturally humble, accessible services and policies that reduce barriers.

Key Findings

Distal stressors were directly related to anxiety in TGNC people of color.

  • Direct effect of distal stressors on anxiety: β = 0.42, 95% CI = 0.26, 0.58
  • Indirect effect of distal stressors on anxiety (through proximal stressors): β = 0.16, 95% CI = 0.07, 0.26
  • Path analysis was conducted using structural equation modeling
  • Sample consisted of 149 TGNC POC U.S. adults surveyed via online cross-sectional survey
  • Anxiety was measured using the Generalized Anxiety Disorder-7 (GAD-7)

Distal stressors were directly and indirectly related to depression in TGNC people of color.

  • Direct effect of distal stressors on depression: β = 0.43, 95% CI = 0.26, 0.60
  • Indirect effect of distal stressors on depression (through proximal stressors): β = 0.14, 95% CI = 0.04, 0.23
  • Depression was measured using the Patient Health Questionnaire-9 (PHQ-9)
  • Distal stressors were measured using the LGBT People of Color Microaggressions Scale
  • Proximal stressors were measured using the Gender Minority Stress and Resilience Measure

Intersectional distal stress was not directly related to gender congruence but was indirectly related through proximal stressors.

  • Indirect effect of distal stressors on gender congruence through proximal stressors: β = -0.16, 95% CI = -0.27, -0.05
  • No significant direct relationship between intersectional distal stress and gender congruence was found
  • Gender congruence was measured using the Gender Congruence and Life Satisfaction Scale (GCLS)
  • Authors cautioned interpretation given low reliability of the GCLS

A large majority of TGNC POC participants desired legal name and gender marker changes, but fewer than 60% who wanted changes were able to obtain them.

  • 91.3% of participants desired a legal name change
  • 98% desired a gender marker change
  • Less than 60% of those who wanted document changes were able to obtain them
  • Participants who had incongruent documents reported negative outcomes as a result

The majority of TGNC POC participants who desired gender-affirming hormone therapy were able to obtain it, but a notable proportion were not.

  • 78.2% of those who wanted gender-affirming hormone therapy were able to obtain it
  • The subsample who wanted hormone therapy was n = 55
  • This implies approximately 21.8% who desired hormone therapy were unable to access it

The study used a sample of TGNC people of color to address a gap in the literature, as most prior studies on the Gender Minority Stress Model have utilized White TGNC samples.

  • The online cross-sectional survey included n = 149 TGNC POC U.S. adults
  • Few prior studies have examined the intersectionality of racial-minority related stress within the Gender Minority Stress Model
  • The Gender Minority Stress Model outlines adverse mental and physical health outcomes due to gender-minority stress
  • Measures included demographics, transition experiences, intersectional distal stressors, proximal stressors, gender congruence, depression, and anxiety

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Citation

Dalton M, Secrest S, Hoffmann A, Nash M, Patel D, Salas J, et al.. (2026). Centering transgender and gender nonconforming people of color in the study of minority stress, transition-related factors, and mental health.. Frontiers in public health. https://doi.org/10.3389/fpubh.2026.1716010