Sleep

Change in sleep duration following a cancer diagnosis.

TL;DR

Participants who received a cancer diagnosis had higher odds of increasing sleep duration (OR = 1.16, 95% CI 1.07, 1.27) compared to participants who did not receive a cancer diagnosis, suggesting that a cancer diagnosis may contribute to increased sleep duration beyond expected age-related changes.

Key Findings

Cancer diagnosis was associated with increased odds of longer sleep duration compared to those without a cancer diagnosis.

  • Odds ratio for increasing sleep duration following cancer diagnosis: OR = 1.16, 95% CI 1.07, 1.27
  • The reference category was 'no change' in sleep duration
  • Results were adjusted for demographic, lifestyle, and health factors using multivariable multinomial logistic regression
  • The association represents change beyond expected age-related changes in sleep duration

The study included 20,210 CPS-3 participants, of whom 4,042 were cancer survivors matched to participants without a cancer diagnosis.

  • Total sample: 20,210 participants
  • Cancer survivors: 4,042 individuals
  • Matching ratio of 1:4 (cancer cases to controls)
  • Matching was based on age, sex, cohort entry year, and timepoint of sleep duration measures
  • CPS-3 is a prospective cohort of US adults aged 30–65 years at baseline (2006–2013)

Sleep duration was measured at three timepoints: baseline (2006–2013), 2015, and 2018, based on self-reported average sleep during the prior year.

  • Sleep duration data collected at baseline, 2015, and 2018 surveys
  • Participants reported average sleep duration during the prior year at each timepoint
  • Change in sleep duration was calculated as the difference between pre-reference and post-reference survey timepoints
  • Change categories were: decrease, no change (reference), and increase

Restricting the analysis to female participants with any cancer diagnosis or breast cancer only yielded similar results to the overall analysis.

  • Female-only subgroup analyses were conducted for any cancer diagnosis and breast cancer specifically
  • Results in these subgroups were consistent with the overall findings
  • No specific OR values for subgroups were reported in the abstract

Cancer incidence was determined through linkage to state cancer registries, providing an objective measure of diagnosis timing.

  • Registry linkage was used to identify cancer diagnoses during study follow-up
  • Only participants with complete sleep data both prior to (pre-reference) and after (post-reference) cancer diagnosis were included
  • This design allowed for within-person change in sleep duration to be assessed relative to the timing of cancer diagnosis

What This Means

This research suggests that being diagnosed with cancer is associated with sleeping more than usual, beyond what would be expected simply from getting older. Using data from a large prospective study of over 20,000 U.S. adults, researchers compared changes in sleep duration between people who received a cancer diagnosis and those who did not, matching them on key characteristics like age and sex. They found that cancer survivors were about 16% more likely to increase their sleep duration after their diagnosis compared to people without a cancer diagnosis. The study collected self-reported sleep data at up to three points in time (around 2006–2013, 2015, and 2018), which allowed the researchers to track how sleep changed before and after a cancer diagnosis. The findings held up when the analysis was limited to women with any cancer or breast cancer specifically, suggesting the pattern is not unique to one cancer type or sex. This research matters because sleep is closely linked to overall health, immune function, and quality of life, and disruptions to sleep are common among people affected by cancer. Understanding how a cancer diagnosis itself—separate from aging—shapes sleep patterns could help healthcare providers better anticipate and address the sleep needs of cancer survivors. It also raises questions about what drives this increase, such as fatigue from treatment, emotional stress, or changes in daily activity, which future studies could explore.

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Citation

Donzella S, Newton C, VoPham T, Peoples A, Bodelon C, Shams-White M, et al.. (2026). Change in sleep duration following a cancer diagnosis.. Cancer causes & control : CCC. https://doi.org/10.1007/s10552-025-02101-4