Chinese Visceral Adiposity Index Outperforms Traditional Anthropometric Indices in Predicting Cardiovascular Disease Risk: A Prospective Cohort Study.

A 1-SD increment of CVAI was associated with the highest elevated risk of incident CVD among all anthropometric indices examined.

• HR (95% CI) for CVD: 1.28 (1.21–1.37) per 1-SD increment of CVAI
• HR (95% CI) for CHD: 1.28 (1.17–1.40) per 1-SD increment of CVAI
• HR (95% CI) for stroke: 1.28 (1.17–1.40) per 1-SD increment of CVAI
• All associations were adjusted for potential confounders
• Indices compared included BMI, waist circumference (WC), waist-hip ratio (WHR), and waist-height ratio (WHtR)

CVAI demonstrated superior predictive performance for CVD compared to BMI and WC in the general population, and additionally outperformed WHR in females.

• AUC of CVAI for predicting CVD was significantly higher than BMI and WC in the general population (p < 0.001)
• CVAI AUC was additionally higher than WHR specifically in females (p < 0.001)
• Predictive performance was assessed using AUROC, continuous net reclassification index (NRI), and integrated discrimination improvement (IDI)
• ROC analysis was used to compare discriminative ability across indices

The study enrolled 35,551 individuals without a history of CVD from the Shanghai Suburban Adult Cohort and Biobank (SSACB).

• This was a prospective cohort study design
• Participants had no prior history of CVD at enrollment
• Cox proportional hazard models with restricted cubic splines were used to evaluate associations
• Outcomes assessed included incident CVD, coronary heart disease (CHD), and stroke

Subgroup analyses revealed different associations between CVAI and CVD risk across age and diabetic groups.

• Subgroup analyses were performed across age, sex, hypertension, and diabetic groups
• Differential associations were specifically noted across age and diabetic subgroups
• CVAI showed particularly promising predictive potential among females
• No specific HRs for subgroups are reported in the abstract

CVAI is a Chinese-specific visceral adiposity index evaluated against traditional anthropometric indices including BMI, WC, WHR, and WHtR for CVD risk prediction in a Chinese population.

• Traditional indices compared were body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and waist-height ratio (WHtR)
• CVAI is described as a Chinese-specific index designed to capture visceral adiposity
• The study population was drawn from a Chinese suburban cohort
• The study aimed to assess whether CVAI outperforms established anthropometric measures in this population