Cardiovascular

Clinical study of isokinetic training with joint control tasks on lower limb function in stroke patients with proprioceptive impairment: a preliminary randomized controlled trial.

TL;DR

Isokinetic joint control training combined with conventional rehabilitation was associated with improvements in proprioceptive function, lower-limb motor performance, and activities of daily living in stroke patients with proprioceptive impairment, and may serve as a useful adjunct to stroke rehabilitation, though more rigorous studies are needed.

Key Findings

Fifty-eight stroke patients with proprioceptive impairment were randomized equally to an experimental or control group in a 4-week trial.

  • Patients were recruited at the Department of Rehabilitation Medicine, Beijing Tiantan Hospital, between April 2025 and November 2025.
  • Allocation used a random number table, with 29 patients per group.
  • Both groups received conventional rehabilitation for 4 weeks; the experimental group additionally received isokinetic training with joint control tasks.

The control group (conventional rehabilitation alone) improved significantly from baseline on all proprioceptive, motor, and ADL measures.

  • Measures that improved significantly (P < 0.05) were the Modified Nottingham Sensory Assessment (NSA), Joint Position Reproduction (JPR) at 30°, 45°, and 60°, and Threshold to Detect Passive Motion (TTDPM).
  • Berg Balance Scale (BBS), Fugl-Meyer Assessment for the lower extremity (FMA-LE), and Modified Barthel Index (MBI) also improved significantly (P < 0.05).

The experimental group (conventional rehabilitation plus isokinetic joint control training) also improved significantly from baseline on all measured indicators.

  • All indicators (NSA, JPR at 30°/45°/60°, TTDPM, BBS, FMA-LE, MBI) showed significant improvement after intervention (P < 0.05).

Proprioceptive improvements were significantly greater in the experimental group than in the control group.

  • Changes in NSA, JPR (30°, 45°, 60°), and TTDPM scores were significantly higher in the experimental group (P < 0.05).
  • Between-group comparisons were of pre-to-post change scores.

Motor function and balance gains were larger in the experimental group than in the control group.

  • The experimental group exhibited larger gains in BBS and FMA-LE scores (P < 0.05).

Activities of daily living improved more in the experimental group than in the control group.

  • MBI score improvements were greater in the experimental group (P < 0.05).

The authors conclude the approach may be a useful adjunct to stroke rehabilitation but that results are preliminary and need confirmation.

  • The trial is described as preliminary, with a modest sample of 58 patients at a single center.
  • The authors state further studies with more rigorous designs are required to confirm these results.

What This Means

This small trial tested whether adding a specialized strength-and-movement machine training, called isokinetic training with joint control tasks, to usual rehabilitation could help stroke survivors who have trouble sensing the position and movement of their limbs. Fifty-eight patients at one hospital in Beijing were randomly split into two groups of 29. Both groups did standard rehabilitation for four weeks, and one group also did the isokinetic training. Both groups got better on measures of joint sensation, leg movement, balance, and daily living skills. However, the group that also received isokinetic training improved more on every one of these measures, including joint position sense, the ability to detect passive movement, balance, lower-limb motor function, and everyday activity scores. This research suggests isokinetic joint control training could be a helpful add-on to stroke rehabilitation for people with impaired limb sensation. However, the study was small, done at a single center, and described by the authors as preliminary, so larger and more rigorous studies are needed before firm conclusions can be drawn.

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Citation

Zhang Z, Yu H, Li P, Li N, Zhang Y. (2026). Clinical study of isokinetic training with joint control tasks on lower limb function in stroke patients with proprioceptive impairment: a preliminary randomized controlled trial.. Frontiers in neurology. https://doi.org/10.3389/fneur.2026.1881854