Cardiovascular

Comparative cost analysis of Eluvia™ versus Zilver® PTX® in treating femoropopliteal peripheral artery disease utilizing real-world data.

TL;DR

Across patients undergoing femoropopliteal endovascular revascularization, Eluvia was associated with significantly lower post-discharge cumulative hospital-based follow-up costs than Zilver PTX while index procedure costs were comparable; these are hospital-based costs only and should not be interpreted as total healthcare costs.

Key Findings

The study included 7208 patients in the Premier Healthcare Database who underwent femoropopliteal endovascular revascularization with either Eluvia (n=4218) or Zilver PTX (n=2990).

  • Retrospective study of adults treated between 1 April 2019 and 31 March 2022.
  • Costs were compared for the index procedure and for cumulative 1- and 2-year post-discharge follow-up.
  • Multivariable generalized linear models adjusted for age, sex, race and baseline chronic limb-threatening ischemia (CLTI) status.

Patients treated with Eluvia had a higher prevalence of several comorbidities than those treated with Zilver PTX.

  • The comorbidities included congestive heart failure and chronic kidney disease (CKD).
  • The abstract does not give the prevalence figures for these comorbidities.

Index procedure hospital-based costs were similar between Eluvia and Zilver PTX, both before and after adjustment.

  • Unadjusted mean costs were $28,631 for Eluvia vs $28,359 for Zilver PTX (difference, -$272; p = 0.7233).
  • After adjustment, mean index procedure costs did not differ significantly between groups (adjusted mean $30,031; p = 0.8491).

Eluvia was associated with lower adjusted cumulative hospital-based costs than Zilver PTX at 1 year and 2 years after discharge.

  • 1-year difference: $4,017 (p = 0.0066).
  • 2-year difference: $6,250 (p = 0.0021).
  • Costs were derived from multivariable generalized linear models.

The lower follow-up costs with Eluvia were also seen in the hospital inpatient and CKD subgroups, but not in the CLTI subgroup.

  • Prespecified subgroups were care setting (hospital inpatient and hospital outpatient), CKD and CLTI.
  • No statistically significant differences in hospital-based costs were observed in the CLTI subgroup.

The cost findings are limited to hospital-based costs captured within participating hospitals and cannot be read as total healthcare cost differences or as causal.

  • Medication costs and costs of care received outside the Premier Healthcare Database were not included.
  • Healthcare utilization was not directly evaluated, so the reasons for the cost differences remain uncertain.
  • The study design is retrospective and observational, so it cannot prove that the stent caused the lower costs.

What This Means

This study used hospital records from more than 7,000 US adults who had a stent placed to reopen a blocked artery in the thigh or behind the knee. It compared hospital-based costs for two drug-coated stents, Eluvia and Zilver PTX. The cost of the initial procedure was about the same for both stents. After patients went home, however, those who received Eluvia had lower hospital costs over the next one and two years. The difference was about $4,017 at one year and $6,250 at two years after accounting for age, sex, race and whether patients had severe limb-threatening circulation problems. The lower follow-up costs also appeared in patients treated during a hospital stay and in patients with kidney disease. They were not seen in patients with severe limb-threatening circulation problems, where the two stents did not differ significantly in cost. Patients who received Eluvia had more other health conditions, such as heart failure and kidney disease, yet still had lower follow-up hospital costs. This research suggests Eluvia may be linked to lower later hospital costs, but it has important limits. The study looked back at existing records, so it cannot show that the stent itself caused the savings. It did not measure why costs differed, such as how often patients returned to the hospital. It also left out medication costs and any care received outside the participating hospitals. The results should therefore be read as hospital costs only, not total healthcare costs.

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Citation

Genovese E, Williams A, Sato R, McGovern A, Jaff M. (2026). Comparative cost analysis of Eluvia™ versus Zilver® PTX® in treating femoropopliteal peripheral artery disease utilizing real-world data.. Journal of comparative effectiveness research. https://doi.org/10.57264/cer-2026-0126