Exercise & Training

Comparing Acute Effects of Caffeine Delivery Forms on Cross-Training Performance: A Randomized Placebo-Controlled Crossover Trial.

TL;DR

While caffeine delivery forms did not improve internal load measures or performance parameters such as RPE, HR, or total number of repetitions, caffeine mouth rinse showed a potentially meaningful improvement in CMJ performance after CrossFit training.

Key Findings

Caffeine mouth rinse (CMR) significantly improved countermovement jump (CMJ) performance compared to baseline, while other caffeine delivery forms did not.

  • CMR produced a change of Δ: +3.5 cm in CMJ performance
  • Effect size was Cohen's dunb: 0.51, indicating a moderate effect
  • The improvement exceeded the estimated smallest worthwhile change (SWC) by approximately three-fold
  • No changes in CMJ were observed with caffeine capsule (CC) or caffeine chewing gum (CCG)

No significant differences were found between any caffeine delivery forms in internal load measures.

  • Rate of perceived exertion (RPE), maximum heart rate (HRmax), and mean heart rate (HRmean) showed no significant differences between conditions
  • The inferential analysis revealed no significant main effects of the caffeine administration method on any measured outcomes
  • Conditions compared included caffeine capsule (CC), caffeine chewing gum (CCG), caffeine mouth rinse (CMR), and a placebo group (PG)

No significant differences were found between caffeine delivery forms in the total number of repetitions performed during the 'Cindy' CrossFit protocol.

  • The total number of repetitions was tracked at the end of the workout for all four conditions
  • The inferential analysis revealed no significant main effects of caffeine administration method on repetition count
  • This finding was consistent across all three caffeine delivery forms (CC, CCG, CMR) compared to placebo

The study employed a randomized, placebo-controlled, crossover design with fourteen trained male CrossFit participants.

  • Participants had more than six months of continuous CrossFit training experience
  • Sample characteristics: age 30.9 (±5.62) years, height 179 (±1.33) cm, weight 78 (±5.75) kg, BMI 24.3 (±1.33) kg·m-2
  • A 7-day washout period was used before each crossover condition
  • Participants were blinded to whether any delivery method contained caffeine
  • Caffeine was administered 30 minutes prior to training to replicate real-world athlete pre-workout routines

The study used the 'Cindy' CrossFit protocol as the exercise intervention with CMJ measured pre- and post-intervention as the primary outcome.

  • CMJ was measured before and after the intervention as the primary outcome measure
  • RPE, heart rate, and number of repetitions were tracked at the end of the workout as secondary outcomes
  • The protocol was designed to ensure ecological validity by mirroring typical athlete pre-workout routines

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Citation

Vargas-Molina S, Bonilla D, García-Sillero M, Iglesias-Placed S, Murri M, Martín-Rivera F, et al.. (2026). Comparing Acute Effects of Caffeine Delivery Forms on Cross-Training Performance: A Randomized Placebo-Controlled Crossover Trial.. Nutrients. https://doi.org/10.3390/nu18040657