Correlation between Chinese visceral adiposity index and incidence of hypertension across different blood pressure status: a cohort study.

Among 5311 participants followed for 9 years, 1,819 (34.25%) developed hypertension during the follow-up period.

• Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS) database.
• Participants were aged ≥45 years without hypertension at baseline (2011) and followed up until 2020.
• The incidence rate of hypertension was 34.25% over the 9-year follow-up period.
• This was a retrospective cohort analysis design.

CVAI was an independent risk factor for incident hypertension in participants with normal blood pressure at baseline.

• Comparing the highest to the lowest quartile of CVAI, the adjusted odds ratio was 1.77 (95% CI: 1.32–2.38) in the normal BP group.
• A linear dose-response relationship was observed between CVAI and hypertension risk in the normal BP group.
• Multivariate logistic regression and restricted cubic spline (RCS) models were used to evaluate the association.
• The association remained robust and linear in sensitivity analyses after excluding participants with diabetes, heart disease, or stroke.

CVAI was an independent risk factor for incident hypertension in participants with elevated blood pressure at baseline, with a stronger association than in the normal BP group.

• Comparing the highest to the lowest quartile of CVAI, the adjusted odds ratio was 3.21 (95% CI: 2.26–4.61) in the elevated BP group.
• The OR of 3.21 in the elevated BP group was substantially higher than the OR of 1.77 in the normal BP group.
• A linear dose-response relationship was also observed between CVAI and hypertension risk in the elevated BP group.
• Sensitivity analyses using univariate RCS models confirmed robustness of findings in this group.

The CVAI is a sex-specific composite index calculated from age, waist circumference, BMI, triglycerides, and HDL-C, designed to reflect the metabolic profile of Asian populations.

• CVAI was calculated using a sex-specific formula incorporating age, waist circumference (WC), body mass index (BMI), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C).
• The index is described as 'a well-established indicator based on the metabolic profile of Asian populations.'
• CVAI has been linked to an increased risk of hypertension in prior research.
• CVAI is characterized as 'a simple, low-cost tool' for hypertension risk stratification.

ROC curve analysis was performed to evaluate the predictive ability of CVAI for hypertension incidence.

• Receiver operating characteristic (ROC) curve analysis was used to assess the discriminative performance of CVAI.
• The analysis was conducted across both the normal BP and elevated BP groups.
• Specific AUC values were not reported in the abstract.
• CVAI was described as offering improved hypertension risk stratification, particularly among individuals with elevated BP.

The associations between CVAI and hypertension risk were robust after sensitivity analyses excluding participants with comorbid conditions.

• Sensitivity analyses employed univariate RCS models to assess robustness.
• Participants with diabetes, heart disease, or stroke were excluded in the sensitivity analyses.
• The linear dose-response relationship between CVAI and hypertension risk was maintained in both BP groups after exclusions.
• Results were described as 'robust and linear' following these sensitivity analyses.