Correlation between visceral adiposity index, body roundness index, lipid accumulation product and the risk and severity of knee osteoarthritis.

The KOA group had significantly higher BMI, TG, TC, LDL-C, VAI, BRI, and LAP, and lower HDL-C compared to healthy controls.

• 124 patients with clinically and radiographically confirmed KOA were compared to 120 healthy controls
• All differences were statistically significant (p < 0.05)
• Baseline data were collected retrospectively from electronic medical records
• KOA diagnosis was confirmed both clinically and radiographically

VAI, BRI, and LAP increased progressively with KOA severity and showed positive correlations with disease severity.

• KOA patients were classified into mild, moderate, and severe subgroups based on K-L grading
• Progressive increases across severity subgroups were statistically significant (p < 0.05)
• Correlation coefficients were r = 0.608 for VAI, r = 0.489 for BRI, and r = 0.551 for LAP (all p < 0.001)
• All three indices were confirmed as independent risk factors for KOA (p < 0.05)

ROC analysis demonstrated that VAI, BRI, and LAP each had moderate discriminatory ability for KOA, with VAI and LAP performing similarly.

• AUC for VAI was 0.775 (95% CI: 0.718–0.833; cutoff: 2.91)
• AUC for BRI was 0.752 (95% CI: 0.692–0.813; cutoff: 5.21)
• AUC for LAP was 0.779 (95% CI: 0.722–0.836; cutoff: 48.58)
• BRI had the lowest individual AUC among the three indices

Combined detection of VAI, BRI, and LAP provided superior predictive value for KOA compared to any individual index.

• Combined AUC was 0.880 (95% CI: 0.839–0.922)
• This represents a substantial improvement over individual AUCs ranging from 0.752 to 0.779
• The combined model incorporated all three adiposity indices together

Survival time over 12 months differed significantly across patient groups stratified by the cutoff values of VAI, BRI, and LAP.

• Patients were followed for 12 months after enrollment
• VAI stratification yielded χ² = 4.238 (p < 0.05)
• BRI stratification yielded χ² = 3.956 (p < 0.05)
• LAP stratification yielded χ² = 6.043 (p < 0.05)
• Higher values above cutoffs were associated with unfavorable prognosis