Auraptene, a coumarin from citrus peels, mitigates CCl4-induced acute liver injury in mice, reducing inflammatory and apoptotic factors in a manner dependent on the TLR2 signaling pathway.
Auraptene pretreatment significantly decreased the expression of liver injury markers in CCl4-induced acute liver injury in mice.
Auraptene reduced inflammatory factors associated with pyroptosis/inflammasome signaling.
Auraptene reduced apoptosis factors in the injury model.
The anti-inflammatory and antiapoptotic effects of auraptene depended on the TLR2 signaling pathway.
Auraptene, a food-derived citrus compound, effectively mitigates CCl4-provoked acute hepatic injury.
This study examined whether auraptene, a natural compound found in citrus peels, can protect the liver from sudden damage. Researchers used mice given carbon tetrachloride, a chemical that causes acute liver injury, and also tested liver cells grown in the lab that were exposed to a damaging signal (TGF-β). Mice pretreated with auraptene showed lower levels of liver injury markers, along with reduced signs of inflammation (Caspase-1, GSDMD, IL-1β, IL-18) and of programmed cell death (Caspase-3, Caspase-8, P53). Experiments in which a receptor called TLR2 or its signaling was blocked or silenced suggested that auraptene's protective effects depend on this pathway. This research suggests auraptene from citrus could be a candidate food-derived compound for protecting the liver against acute injury. However, the findings come from mice and cell models, and the abstract gives no human data, so it is not known whether the same effects would occur in people.
Upload your bloodwork. We'll cross-reference your results against this study and 4,700 others.
Upload Your LabsGuo T, Xu Z, Li X, Jia L, Lv M, Wang Q, et al.. (2026). Dietary Supplementation of Auraptene, a Major Component in Citrus reticulata Blanco, Prevents Acute Liver Injury Associated with Apoptosis and Inflammation.. Journal of agricultural and food chemistry. https://doi.org/10.1021/acs.jafc.5c13753