Effect of vitamin D as Nutrition Supplement on Patients with Prolonged Ventilation due to Ventilator Associated Pneumonia and Sepsis Followed Severe Traumatic Lung Contusion: A Randomized Controlled Trial.

Vitamin D deficiency is highly prevalent among critically ill patients in ICU settings.

• Reported rates of vitamin D deficiency range from 40% to 80% in ICU cohorts.
• Deficiency is associated with increased risk for respiratory infections, prolonged ventilation, increased length of stay, and mortality.

Patients receiving high-dose vitamin D supplementation demonstrated significantly faster recovery from lung contusion, VAP, and sepsis.

• Recovery was reflected by lower Murray scores, CPIS scores, and SOFA scores at both week 1 and week 2 in Group B compared to Group A.
• All score differences between groups were statistically significant (p<0.05).
• Group B received cholecalciferol 100,000 IU/day for 14 days in addition to standard enteral nutrition.
• Patients were enrolled with Murray score >4, CPIS >6, and SOFA score >10 (excluding GCS) at baseline.

Vitamin D supplementation was associated with significantly shorter duration of mechanical ventilation and ICU stay.

• Group B (vitamin D) showed significantly shorter durations of mechanical ventilation compared to Group A (standard nutrition only).
• Group B also showed significantly shorter ICU length of stay compared to Group A.
• Both differences were statistically significant at p<0.001.

Mortality rate was significantly lower in the vitamin D supplementation group compared to the control group.

• Mortality in Group B (vitamin D) was 10.0% versus 27.5% in Group A (standard nutrition).
• The difference in mortality was statistically significant (p=0.045).
• The trial included 80 adult ICU patients, with 40 patients in each group.
• Follow-up period was 14 days.

The study population consisted of adult ICU patients with severe traumatic lung contusion who developed VAP and sepsis after prolonged mechanical ventilation.

• All patients had remained mechanically ventilated for 10 consecutive days before developing VAP and sepsis.
• Inclusion criteria required Murray score >4, CPIS >6, and SOFA score >10 (excluding GCS).
• The trial was a prospective, double-blinded randomized controlled trial with 80 total participants.
• Patients were randomized to either standard enteral nutrition (Group A, n=40) or standard nutrition plus high-dose vitamin D (Group B, n=40).