AL supplementation was associated with more rapid reduction in blood alcohol and acetaldehyde concentrations and lower severity of alcohol-related symptoms, particularly fatigue and cognitive difficulty, compared with placebo in healthy adults.
Key Findings
Results
AL intake was associated with a more rapid reduction in blood alcohol concentrations compared with placebo.
Study design was a randomized, double-blind, placebo-controlled, crossover clinical trial
Blood alcohol concentrations were measured at predefined time points up to 13 hours after alcohol consumption
Participants consumed AL or placebo prior to alcohol consumption
The trial was registered retrospectively with the Clinical Research Information Service (CRIS), Republic of Korea (KCT0010612)
Results
AL intake was associated with a more rapid reduction in blood acetaldehyde concentrations compared with placebo.
Acetaldehyde concentrations were measured at predefined time points up to 13 hours after alcohol consumption
Acetaldehyde is a toxic metabolite of alcohol associated with hangover symptoms
The amino acid mixture AL was suggested to support hepatic metabolism following alcohol consumption
Results
Participants who received AL reported lower severity of alcohol-related symptoms compared with placebo.
Alcohol-related symptoms were assessed using the Alcohol Hangover Severity Scale (AHSS)
Lower symptom severity was observed particularly for fatigue and cognitive difficulty
Symptom differences were noted at 13 hours after alcohol consumption
Results
No clinically significant adverse effects were observed with AL supplementation.
Safety parameters were evaluated as part of the study protocol
The study involved healthy adult participants
AL is described as an amino acid mixture intended as a nutritional approach
Methods
The study used a crossover design in which healthy adults consumed AL or placebo prior to alcohol consumption.
The trial design was randomized, double-blind, placebo-controlled, and crossover
Blood alcohol and acetaldehyde concentrations were measured at predefined time points up to 13 hours after alcohol consumption
The trial was retrospectively registered on 10 June 2025 with CRIS (KCT0010612)
Kim H, Suh H, Han K, Kim N, Jung E, Shim J. (2026). Effects of an amino acid mixture on alcohol metabolism and alcohol-related symptoms in healthy adults.. Scientific reports. https://doi.org/10.1038/s41598-026-35178-1