Efficacy and safety of a nutritional supplement based on vitamins, minerals, amino acids and plant extracts on a large population of older adults experiencing fatigue.
Daily intake of a specially formulated nutritional supplement (ApportAL®) resulted in a progressive improvement of both fatigue and quality of life in older adults, with significant improvements observed as early as after the first week of supplementation.
Key Findings
Results
The nutritional supplement produced a 46% improvement in worst fatigue experienced and a 47.5% improvement in fatigue interference score over 35 days.
458 individuals were recruited with an average age of 69 ± 10 years, 63.5% women
Fatigue was assessed at baseline (T0), after 7 days (T1), and after 35 days (T2)
Worst fatigue experienced improved by 46%
Interference score of fatigue improved by 47.5%
Improvement was significant after the first week and increased further over the remaining 4 weeks
Results
Quality of life improved in both physical and mental components following supplementation.
Physical component of quality of life improved by 29%
Mental component of quality of life improved by 77.4%
Improvements were assessed using questionnaires at T0, T1, and T2
A significant improvement was observed as early as after the first week of supplementation
Results
Self-reported adverse events were mild and decreased in prevalence over the course of supplementation.
10.3% of individuals reported adverse events at T1 (after 7 days)
8.5% of individuals reported adverse events at T2 (after 35 days)
Adverse events were described as mild
The percentage of affected individuals decreased from T1 to T2
Methods
The supplementation protocol involved two sachets per day for the first 7 days followed by one sachet per day for the remaining 28 days.
Supplement used was ApportAL® (Pharmanutra Spa, Pisa, Italy), based on vitamins, minerals, amino acids, and plant extracts
Total supplementation duration was 35 consecutive days
Higher dose (two sachets/day) was administered during the first 7 days
Participants were diagnosed with fatigue by their general practitioners prior to inclusion
Study design was a prospective observational study
Results
The study population consisted of 458 older adults (>50 years) experiencing fatigue, with a majority being women.
Total recruited: 458 individuals
63.5% were women
Average age was 69 ± 10 years
Participants were diagnosed with fatigue by their general practitioners
Two questionnaires were used to assess fatigue and quality of life at three time points
Giovannini S, Castelli L, Iacovelli C, Loreti C, Biscotti L, Rossato M, et al.. (2026). Efficacy and safety of a nutritional supplement based on vitamins, minerals, amino acids and plant extracts on a large population of older adults experiencing fatigue.. Nutricion hospitalaria. https://doi.org/10.20960/nh.06137