Portable ultrasound-guided pingyangmycin sclerotherapy is a feasible and well-tolerated outpatient-based procedure for patients with deep-seated oral and maxillofacial venous malformations.
All 49 outpatients experienced symptom relief after portable ultrasound-guided pingyangmycin sclerotherapy, with a significant drop in global discomfort NRS scores.
Sclerotherapy produced a substantial reduction in lesion volume, with a mean decrease of 82% across all patients.
Most lesions showed excellent or moderate volumetric response, and only a small fraction showed mild response.
Treatment required a median of about 2 sessions per patient, with a range of 1 to 5.
No severe complications occurred with the procedure.
This study looked back at 49 outpatients with venous malformations (abnormal clusters of veins) located deep in the mouth and face area. They were treated with pingyangmycin, a sclerosing drug injected into the lesion under guidance from a portable ultrasound machine. Patients had a median of about 2 sessions, with a range of 1 to 5. After treatment, all patients reported symptom relief. Their discomfort scores on a 0-10 scale fell from a median of 5 to a median of 0. Lesions shrank by 82% on average, from about 3.6 cm³ to 0.5 cm³. Around 43% of lesions shrank by 90% or more, 47% shrank by 50-90%, and about 10% shrank by less than half. No severe complications were reported. This research suggests that ultrasound-guided pingyangmycin injection performed in an outpatient setting may be a practical and well-tolerated option for these hard-to-reach lesions. However, the study was retrospective, had no comparison group, and was relatively small, so the findings should be confirmed in larger, controlled studies.
Wang Q, Sun X, Zhao C, Wu J, Bai H, Zheng J. (2026). Efficacy and safety of portable ultrasound-guided pingyangmycin sclerotherapy for deep-seated oral and maxillofacial venous malformations: a retrospective observational study.. Frontiers in neurology. https://doi.org/10.3389/fneur.2026.1932113