Efficacy and Safety of Steamed Ginger Extract for Body Weight and Body Fat Reduction in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Twelve weeks of GGE03 supplementation were associated with statistically significant improvements in body composition and lipid parameters without safety concerns, supporting the potential of 1-dehydro-6-gingerdione-standardized steamed ginger extract as a well-tolerated functional dietary ingredient for body fat management and metabolic health.
Key Findings
Results
GGE03 supplementation produced statistically significant reductions in body fat percentage and body fat mass compared to placebo after 12 weeks.
Measurements were conducted using dual-energy X-ray absorptiometry (DEXA)
The trial was randomized, double-blind, and placebo-controlled
GGE03 was administered at 480 mg/day for 12 weeks
Participants were overweight adults with BMI 25.0–29.9 kg/m2
Results
GGE03 supplementation was associated with significant decreases in body weight, BMI, waist circumference, and hip circumference.
These anthropometric outcomes were evaluated at baseline and after the 12-week intervention period
The GGE03 group consisted of n = 40 participants receiving 480 mg/day
The placebo group consisted of n = 40 participants
Participants were adults aged 18 to 60 years
Results
Serum triglyceride and total cholesterol levels were significantly lower in the GGE03 group compared to the placebo group after 12 weeks.
Both triglyceride (TG) and total cholesterol (TC) were assessed as efficacy parameters
Comparisons were made between the GGE03 group (n = 40) and placebo group (n = 40)
Lipid parameters were evaluated at baseline and after the 12-week intervention period
Results
GGE03 was well tolerated, with no product-related adverse events or clinically significant laboratory abnormalities observed.
Safety parameters were evaluated at baseline and after the 12-week intervention period
No product-related adverse events were noted across the study population of 80 adults
No clinically significant laboratory abnormalities were identified
Methods
The study investigated a steamed ginger extract (GGE03) standardized to high levels of 1-dehydro-6-gingerdione (GD) as the active ingredient.
GGE03 was standardized to 1-dehydro-6-gingerdione (GD), a compound derived from the steaming process of ginger
The daily dose was 480 mg/day administered orally for 12 weeks
Eighty overweight adults aged 18–60 years with BMI 25.0–29.9 kg/m2 were enrolled and randomized equally to two groups
Kwon J, Lee Y, Kim I, Bae J, Kang S, Baek H. (2026). Efficacy and Safety of Steamed Ginger Extract for Body Weight and Body Fat Reduction in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.. Nutrients. https://doi.org/10.3390/nu18020366