Cardiovascular

Epidemiology of uncontrolled and treatment‑resistant hypertension: a registry‑based observational study.

TL;DR

Among diagnosed hypertensive individuals in Stockholm County, 57% had blood pressure below 140/90 mmHg and only 19% below 130/80 mmHg, while the point prevalence of treatment-resistant hypertension ranged from <1% to 17% depending on the definition used and was associated with older age, higher BMI and multiple comorbidities.

Key Findings

Only about 57% of individuals with a hypertension diagnosis had controlled blood pressure at the conventional <140/90 mmHg target by the end of 2019.

  • Setting: randomly selected adults registered in Stockholm County, Sweden, on December 31st, 2019, with at least one primary or secondary healthcare visit.
  • The study covered more than 400,000 adults, using healthcare records, blood pressure measurements, and pharmacy dispensing data.
  • Control was assessed among those with a hypertension diagnosis.

Fewer than one in five diagnosed hypertensive individuals (19%) achieved the more intensive <130/80 mmHg target.

  • The abstract states that 19% had controlled blood pressure at <130/80 mmHg.
  • The <130/80 mmHg target is recommended for many patients in contemporary guidelines.
  • The authors describe a gap between guideline recommendations and routine clinical practice.

The point prevalence of treatment-resistant hypertension varied widely, from <1% to 17%, depending on which of three commonly used definitions was applied.

  • Three commonly used criteria for treatment-resistant hypertension were applied.
  • Resistance was assessed using evidence that medications had been dispensed, not merely prescribed.
  • The authors suggest this definitional sensitivity may partly explain the wide differences in prevalence reported across previous studies.

Treatment-resistant hypertension was associated with older age, higher body mass index, and multiple comorbidities.

  • Associated comorbidities included type 2 diabetes, cardiovascular disease, heart failure, and chronic kidney disease.
  • Drug treatment patterns were also assessed in relation to treatment-resistant hypertension.
  • The authors conclude that treatment-resistant hypertension is closely associated with a greater burden of comorbidities.

Many patients lacked suitable follow-up blood pressure measurements, indicating potential gaps in routine care.

  • This is noted as a limitation of the available data and also as a clinical care gap.
  • The authors point to opportunities to improve blood pressure monitoring, treatment optimisation, and cardiovascular risk reduction.

The authors conclude that blood pressure control remains a major clinical challenge and that there is an unmet need for improved strategies for patients with treatment-resistant hypertension.

  • Uncontrolled hypertension remains a major challenge in everyday clinical practice.
  • The treatment-resistant subgroup carries a high comorbidity burden.

What This Means

This study looked at more than 400,000 adults in Stockholm County, Sweden, using routine healthcare records, blood pressure readings and pharmacy dispensing data. Among people who had been diagnosed with high blood pressure, just over half (57%) had readings below 140/90 mmHg by the end of 2019. Only about one in five (19%) reached the stricter target of 130/80 mmHg, which many current guidelines recommend for many patients. The study also estimated how common treatment-resistant hypertension is, meaning blood pressure that stays high despite multiple medications. The estimate ranged from under 1% to 17% depending on which of three commonly used definitions was applied, suggesting that differences in definitions may help explain why earlier studies reported such different numbers. People with treatment-resistant hypertension tended to be older, to have a higher body mass index, and to have conditions such as type 2 diabetes, cardiovascular disease, heart failure and chronic kidney disease. This research suggests that controlling blood pressure in everyday care remains difficult, especially at stricter targets, and that people with resistant hypertension carry a heavy burden of other illnesses. Many patients also lacked suitable follow-up blood pressure measurements, which suggests room to improve monitoring and treatment adjustment in routine care. The study is observational, so it describes patterns rather than showing causes.

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Citation

Shojaiyan P, Sundstr&#xf6;m J, Brunstr&#xf6;m M, Karlberg O, Henrohn D. (2026). Epidemiology of uncontrolled and treatment&#x2011;resistant hypertension: a registry&#x2011;based observational study.. Blood pressure. https://doi.org/10.1080/08037051.2026.2749134