Epigenetic Role of Gastrointestinal Microbiota in Individuals Receiving Hemodialysis.

Statistically significant correlations were found between a subset of GI microbiota and miRNA in hemodialysis patients.

• A cross-sectional descriptive correlational study design was used.
• Survey data, stool, and blood specimens were collected from 20 patients at a local dialysis clinic.
• The correlations were identified between specific subsets of GI microbiota and miRNA.

GI microbiota and miRNA profiles differed between groups with varying levels of fiber intake.

• Fiber intake was identified as a potentially modifiable dietary factor.
• Differences in GI microbiota and miRNA subsets were associated with different levels of fiber consumption.
• Survey data were used alongside biological specimens to assess dietary patterns.

GI microbiota and miRNA profiles differed between groups with varying levels of physical activity.

• Physical activity was identified as a potentially modifiable lifestyle factor.
• Differences in GI microbiota and miRNA subsets were associated with varying levels of physical activity.
• Both fiber intake and physical activity were suggested as factors to modulate the epigenetic role of GI microbiota.

GI microbiota may play an epigenetic role in individuals receiving hemodialysis through regulation of miRNA.

• The study explored the epigenetic roles GI microbiota play in hemodialysis patients.
• Burgeoning evidence suggests GI microbiota regulate physiologic homeostasis and may influence adverse symptoms experienced by hemodialysis patients.
• Findings were suggested to provide insights into additional therapeutic targets for this population.

Nephrology nurses were identified as having a critical role in optimizing lifestyle factors related to GI microbiota and epigenetic outcomes in hemodialysis patients.

• Diet and exercise were highlighted as modifiable factors that nephrology nurses could address.
• The findings were framed as allowing nephrology nurses to play a critical role in optimizing individuals' lifestyle factors.
• The study was conducted at a local dialysis clinic with a sample of 20 patients.