Using different software programs to evaluate body composition in patients with cirrhosis showed excellent agreement for measuring muscle mass and adipose depots.
Key Findings
Results
Interobserver intraclass correlation coefficients (ICCs) were highly equivalent for all body composition measures analyzed.
ICC range for interobserver comparisons was 0.984-0.999 (P < 0.001)
Measures included CSMA, SMI, MA, VAT, VATI, SAT, and SATI
Fifty patients were randomly selected from two centers
Two observers independently evaluated each CT scan
Results
Intersoftware intraclass correlation coefficients were highly equivalent for all body composition measures.
ICC range for intersoftware comparisons was 0.984-0.999 (P < 0.001)
The two software programs compared were SliceOmatic V.5.0 (Magog, Canada) and Synapse 3D, Fujifilm
All seven body composition parameters showed excellent agreement between the two software programs
Results
Pearson's correlation coefficients were excellent for all interobserver and intersoftware comparisons.
Pearson's correlation coefficient range was 0.970-0.998 across all comparisons
Excellent correlations were found for both interobserver and intersoftware comparisons
All body composition parameters including muscle and adipose measures demonstrated this level of correlation
Methods
The study evaluated cross-sectional body composition analysis using abdominal CT scans in patients with cirrhosis from two centers.
Fifty patients were randomly selected from two centers
Body composition measures analyzed included cross-sectional muscle area (CSMA), skeletal muscle index (SMI), muscle attenuation (MA), visceral adipose tissue area (VAT), visceral adipose tissue index (VATI), subcutaneous adipose tissue area (SAT), and subcutaneous adipose tissue area index (SATI)
Abdominal CT evaluation was identified as the technique that is better evaluated for body composition in this population
Both interobserver and intersoftware agreements were assessed
D'Arcangelo F, Zanetto A, Dunichand-Hoedl A, Motamedrad M, Burra P, Montano-Loza A. (2026). Evaluation of two software programs for cross-sectional body composition analysis on abdominal computed tomography scans of patients with cirrhosis.. European journal of radiology. https://doi.org/10.1016/j.ejrad.2025.112637