Hormone Therapy

[Evolution of views on the etiology and pathogenesis of lower urinary tract symptoms for men].

TL;DR

LUTS in men is an interdisciplinary problem involving systemic hormonal and metabolic disorders, with testosterone deficiency playing a role in pathogenesis and testosterone replacement therapy showing safety and effectiveness in hypogonadal men with LUTS.

Key Findings

The term 'Lower Urinary Tract Symptoms' (LUTS) replaced the previously used term 'Dysuria' in the literature.

  • LUTS as a term allocates various groups of symptoms depending on the violation of key functions of the bladder
  • The new terminology 'greatly facilitates obtaining reliable information about the state of urination in a particular patient'
  • The review examines this terminological evolution from a methodological and historical point of view

LUTS was historically identified exclusively with urological pathology but is now recognized as an interdisciplinary problem.

  • Fundamental research of recent decades established LUTS as an interdisciplinary problem
  • The condition involves various specialists in the process of diagnosis and correction
  • The shift represents an evolution in understanding the etiology and pathogenesis of LUTS in men

Systemic hormonal and metabolic disorders in men are considered independent factors of LUTS.

  • The influence of systemic hormonal and metabolic disorders is identified as one of the current trends in the study of urination pathophysiology
  • These disorders are considered 'as independent factors of the LUTS'
  • This represents a broader, non-exclusively urological understanding of LUTS etiology

Testosterone deficiency plays a role in the pathogenesis of LUTS in men.

  • The role of testosterone deficiency in the pathogenesis of LUTS is specifically highlighted in the review
  • This is discussed in the context of systemic hormonal disorders as independent contributing factors to LUTS
  • The review situates testosterone deficiency within the broader interdisciplinary framework of LUTS etiology

Testosterone replacement therapy (TRT) demonstrates safety and effectiveness in hypogonadal men with LUTS.

  • The review specifically addresses both the safety and effectiveness of TRT in this population
  • The target population is described as 'hypogonadal men with LUTS'
  • This finding is based on a review of fundamental research from recent decades

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Citation

Tyuzikov I, Tishova Y. (2022). [Evolution of views on the etiology and pathogenesis of lower urinary tract symptoms for men].. Urologiia (Moscow, Russia : 1999). https://pubmed.ncbi.nlm.nih.gov/36382832/