Exploring the association between adiposity, pain intensity, and effusion-synovitis in people with knee osteoarthritis: A cross-sectional study.

Total body fat percentage was not significantly associated with pain intensity in people with knee osteoarthritis after adjusting for confounders.

• Adjusted model yielded β = -0.03 (95% CI: -0.54 to 0.46)
• The association was not statistically significant
• Confounders adjusted for included age, sex, BMI, radiographic severity of the opposite knee, and anxio-depressive symptoms
• Sample consisted of 225 participants with mean age 61.1 (10.9) years, 68% female, mean BMI 31.7 (7.7)

Visceral fat percentage was not significantly associated with pain intensity in people with knee osteoarthritis after adjusting for confounders.

• Adjusted model yielded β = -0.25 (95% CI: -1.03 to 0.51)
• The association was not statistically significant
• Total body and visceral fat percentages were measured using bioimpedance analysis
• Multiple linear regression models were used to examine the association

Total body fat percentage was not significantly associated with effusion-synovitis in people with knee osteoarthritis after adjusting for confounders.

• Adjusted logistic model yielded OR = 0.98 (95% CI: 0.92 to 1.05)
• The association was not statistically significant
• Effusion-synovitis was graded using knee ultrasonography
• Multiple logistic regression models with interaction terms were used

Visceral fat percentage was not significantly associated with effusion-synovitis in people with knee osteoarthritis after adjusting for confounders.

• Adjusted logistic model yielded OR = 1.01 (95% CI: 0.91 to 1.11)
• The association was not statistically significant
• Participants were sampled from the Western Ontario Registry for Early Osteoarthritis Knee Study

Systemic immune-inflammation indicators (SII and SIRI) did not significantly moderate the associations between adiposity and pain intensity or effusion-synovitis.

• Neither the main nor the interaction effects were significant
• The systemic immune-inflammation index (SII) and the systemic immune response index (SIRI) were used as indicators of systemic immune inflammation
• Interaction terms between fat percentages and SII/SIRI were included in regression models
• This suggests generalized inflammation does not moderate the adiposity-pain or adiposity-effusion-synovitis relationship when adjusted for BMI

The study sample consisted of 225 individuals with knee OA with a profile consistent with overweight/obese adults.

• Mean age was 61.1 (SD 10.9) years
• 68% of participants were female
• Mean BMI was 31.7 (SD 7.7), indicating an overweight to obese sample on average
• Participants were drawn from the Western Ontario Registry for Early Osteoarthritis Knee Study