Fish oil supplementation and clinical outcomes in patients with sepsis-associated acute kidney injury: A retrospective cohort study from the MIMIC-IV database.

Fish oil supplementation was associated with lower 21-day mortality in patients with sepsis-associated acute kidney injury.

• Cox regression indicated HR = 0.74, 95% CI: 0.59–0.99, P = 0.032
• Survival analysis showed that the fish oil supplementation group had a higher 21-day survival rate compared to the control group
• Study used propensity score matching with 142 patients in each group drawn from 14,234 total SA-AKI patients in the MIMIC-IV database
• Sensitivity analyses were performed to assess the robustness of the results

Fish oil supplementation was associated with improved renal function recovery in critically ill patients with SA-AKI.

• Logistic regression showed OR = 1.76, 95% CI: 1.03–3.01, P = 0.040
• Renal function recovery was evaluated using logistic regression models
• The matched cohort consisted of 142 fish oil supplementation patients and 142 control patients after propensity score matching

No significant difference in ICU length of stay was observed between the fish oil supplementation group and the control group.

• Linear regression models were employed to evaluate length of hospital stay
• The null finding for ICU length of stay contrasted with the positive findings for mortality and renal function recovery
• Both groups consisted of 142 patients after propensity score matching

The effect of fish oil supplementation on outcomes may vary based on the presence of congestive heart failure and CRRT/RRT treatment status.

• Subgroup analyses were conducted to examine effect modification
• Congestive heart failure and CRRT/RRT treatment status were identified as potential modifiers of the fish oil supplementation effect
• These subgroup findings suggest heterogeneity in treatment response among SA-AKI patients

A retrospective cohort study design using the MIMIC-IV database identified 14,234 patients with SA-AKI, of whom 142 received fish oil supplementation and were matched to 142 controls.

• Propensity score matching was used to balance baseline characteristics between groups
• Cox regression, logistic regression, and linear regression models were employed to evaluate survival, renal function recovery, and length of hospital stay respectively
• The study population consisted of critically ill patients, and SA-AKI was the primary diagnosis of interest
• Sensitivity analyses were performed to assess robustness of results